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Long noncoding RNA ADEI/miR-93-3p/STAT3 axis promotes Epstein-Barr virus-positive diffuse large B-cell lymphoma
Weili Zheng1, Guilan Lai2, Ziyuan Liao3
1Department of Lymphoma and Head and Neck Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China.
Cell Death & Disease
|March 3, 2026
Summary
A novel exosomal long noncoding RNA, lncADEI, promotes Epstein-Barr virus-positive diffuse large B-cell lymphoma (EBV+DLBCL) progression and immune evasion. LncADEI is a potential biomarker and therapeutic target for EBV+DLBCL.
Area of Science:
- Oncology
- Molecular Biology
- Immunology
Background:
- Epstein-Barr virus (EBV) is a key factor in lymphoma development.
- EBV-positive diffuse large B-cell lymphoma (EBV+DLBCL) shows poorer outcomes with standard chemotherapy compared to EBV-negative DLBCL.
- Long noncoding RNAs (lncRNAs) are crucial in cancer regulation and serve as biomarkers, with exosomes acting as carriers for intercellular signaling.
Purpose of the Study:
- To investigate the role of exosomal lncRNAs in the pathogenesis of EBV-related DLBCL.
- To identify and characterize novel lncRNAs involved in EBV+DLBCL progression.
- To explore the potential of exosomal lncRNAs as diagnostic markers and therapeutic targets for EBV+DLBCL.
Main Methods:
- Identification and quantification of lncRNAs in EBV+DLBCL.
- Functional studies to assess the impact of lncADEI on DLBCL cell proliferation, clonogenesis, and immune evasion.
- Investigation of the regulatory pathway involving lncADEI, miR-93-3P, STAT3, and programmed death ligand-1 (PD-L1).
- Analysis of lncADEI expression in serum exosomes from EBV+DLBCL patients.
Main Results:
- A novel lncRNA, lncADEI, was found to be upregulated in EBV+DLBCL.
- LncADEI positively correlated with DLBCL cell proliferation and clonogenesis.
- LncADEI promotes DLBCL proliferation and immune evasion by upregulating STAT3 via miR-93-3P, which in turn activates PD-L1.
- LncADEI is transferable via exosomes and is highly expressed in serum exosomes of EBV+DLBCL patients, correlating with adverse clinicopathological features.
Conclusions:
- LncADEI plays a significant role in the progression and immune evasion of EBV+DLBCL.
- LncADEI exhibits differential expression in serum exosomes, suggesting its potential as a biomarker.
- LncADEI represents a promising therapeutic target for EBV-associated lymphoid malignancies.
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