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SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
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Advancing senescence translation through the Senotherapeutics Biomarker Consortium

Marco Quarta1, Nicola Neretti2, Heinrich Jasper3

  • 1Rubedo Life Sciences, Inc., Sunnyvale, CA, USA. marcoquarta@rubedolife.com.

Nature Aging
|March 3, 2026
PubMed
Abstract

No abstract available in PubMed .

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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Replicative Cell Senescence02:15

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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...

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