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Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
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Atrial cardiomyopathy in cardiac amyloidosis: clinical imaging and manifestations

Natasha Gorrie1,2,3, Paul Geenty4,5, Eleanor Rye6,7

  • 1Victor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia. n.gorrie@victorchang.edu.au.

NPJ Cardiovascular Health
|March 3, 2026
PubMed

Insights

Cardiac amyloidosis can cause atrial cardiomyopathy, impacting heart function and prognosis. This review highlights imaging and clinical outcomes related to this condition.

Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Amyloidosis Research

Background:

  • Cardiac amyloidosis is a progressive infiltrative disease causing significant heart complications.
  • Atrial abnormalities are often seen as secondary to ventricular dysfunction or arrhythmias.
  • Emerging evidence suggests primary atrial defects may occur in cardiac amyloidosis.

Purpose of the Study:

  • To review current evidence on atrial cardiomyopathy in cardiac amyloidosis.
  • To focus on the role of imaging in diagnosing and assessing atrial cardiomyopathy.
  • To correlate imaging findings with clinical outcomes in affected patients.

Main Methods:

  • Literature review of studies on cardiac amyloidosis and atrial cardiomyopathy.
  • Emphasis on diagnostic imaging modalities (e.g., echocardiography, cardiac MRI).
  • Analysis of studies reporting clinical outcomes and prognostic markers.

Main Results:

  • Atrial cardiomyopathy is increasingly recognized as a primary feature in cardiac amyloidosis.
  • Imaging plays a crucial role in detecting structural and functional atrial changes.
  • Atrial cardiomyopathy is associated with adverse clinical outcomes, including arrhythmias and heart failure.

Conclusions:

  • Atrial cardiomyopathy is an important, often under-recognized, component of cardiac amyloidosis.
  • Early identification through imaging may improve prognostic assessment.
  • Further research is needed to fully elucidate the mechanisms and therapeutic implications of atrial cardiomyopathy in this disease.

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