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Building Adaptive School-Based Interventions for Caries (BASICS): study protocol for a Sequential, Multiple
Ryan Richard Ruff1, Tamarinda Barry Godín2, Shulamite Huang2
1Division of Community Oral Health, University of Pennsylvania School of Dental Medicine, 220 S. 40th Street, Philadelphia, PA, 19104, USA. ryanruff@upenn.edu.
Trials
|March 3, 2026
Summary
This study introduces adaptive school-based dental caries prevention to improve treatment response in children. Personalized medicine approaches aim to reduce nonresponse and optimize oral healthcare delivery for better outcomes.
Area of Science:
- Public Health
- Pediatric Dentistry
- Clinical Trials
Background:
- School-based caries prevention is effective but has a ~25% nonresponse rate.
- Children not responding to initial treatment remain at risk for dental caries.
- There is a need for personalized, adaptive interventions in school oral healthcare.
Purpose of the Study:
- To develop and test adaptive preventive interventions for dental caries in school settings.
- To reduce treatment nonresponse by personalizing care based on individual patient attributes.
- To determine the most effective sequence of treatments for caries prevention and optimize resource allocation.
Main Methods:
- Utilizing a Sequential, Multiple Assignment, Randomized Trial (SMART) design.
- Enrolling 1200 children (K-3rd grade) from low-income rural families.
- Employing adaptive treatment pathways based on caries recurrence and patient response.
Main Results:
- This section is not available in the provided abstract.
Conclusions:
- The Building Adaptive School-based Interventions for Caries (BASICS) study aims to create a resource-efficient model for school dental care.
- Optimizing treatment allocation based on patient needs can improve caries prevention efficacy.
- Successful implementation could lead to significant improvements in pediatric oral health outcomes.
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