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Updated: Jul 13, 2026
A New Murine Model of Endovascular Aortic Aneurysm Repair
Published on: July 7, 2013
[Efficacy and safety of local hemostatic solution in reconstructive operations on the aorta in laboratory animals (an
R E Kalinin1, I A Suchkov1, A A Krylov1
1Ryazan State Medical University named after Academician I.P. Pavlov of the Ministry of Health of the Russian Federation, 390026, Ryazan, Russian Federation.
Background:
Most open operative interventions in vascular surgery are performed in conditions of systemic hypocoagulation, thus additionally complicating the achievement of hemostasis. A reliable level of hemostasis in the reconstruction zone is achieved at the expense of observing a series of factors. Frequently, when the traditional methods of hemostasis are not enough for the purpose, the use of local hemostatic agents becomes absolutely necessary.
Objective:
Our study was aimed at investigating the efficacy and safety of using the hemostatic agent 'Hemoblock' to achieve hemostasis during reconstructive operations on the aorta in combination with synthetic materials in a laboratory experiment on animals.
Materials And Methods:
The study included 80 mongrel cats divided into 4 equal groups by blind randomization: 2 experimental groups and 2 control groups. In the vivarium under general anesthesia, the animals underwent surgery - alloplasty of the abdominal aorta. Dacron patches, being woven and knitted prosthetic grafts made of polyester fiber (n=40), and PTFE patches (n=40) were used as the material for alloplasty.
Results And Discussion:
The mean volume of blood loss volume in group 2A (Dacron) and in group 1A (Dacron + Hemoblock) amounted to 15.69 ml and 14.6 ml, respectively, with no significant difference between the groups (p=0.24). The volume of blood loss in group 2B, using PTFE as a plastic material, was 20.12 ml, and in group 1B (PTFE + Hemoblock) it was 14.2 ml. Statistical analysis demonstrated significantly better values obtained with the additional use of Hemoblock (p=0.03). The mean bleeding time in group 2A (Dacron) was 265.8 s and in group 1A (Dacron + Hemoblock) it was 240.6 s, which was a statistically better time to achieve hemostasis (p<0.001). In group 2B (PTFE), the bleeding time was 285 s and in group 1B (PTFE + Hemoblock) it was 259.2 s, with a statistically significant between-group difference in favor of the additional use of Hemoblock (p<0.001).
Conclusion:
Applying the hemostatic solution Hemoblock made it possible to significantly improve the results of surgical interventions in terms of such parameters as reducing blood loss by 29.4% when using PTFE and by 6.9% when using Dacron, as well as to decrease the bleeding time by 9% when using PTFE patches and by 9.5% when using Dacron patches. During the experiment, there were no complications associated with the use of the local hemostatic solution Hemoblock.
