Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

817
Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
817
Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

768
The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
768
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

408
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
408
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

414
Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in...
414
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

632
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
632
Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

2.3K
Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
2.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Balanced crystalloids versus saline and mortality in hospitalized patients: a hierarchical Bayesian meta-analysis of cluster-randomized trials.

Journal of critical care·2026
Same author

The role of hemoadsorption in septic shock: toward a personalized approach.

Critical care (London, England)·2026
Same author

Agreement between intra-bladder and insufflation pressure readings during laparoscopic surgery.

Journal of clinical monitoring and computing·2026
Same author

Hepatic Glycogen Storage Diseases in Brazil: A Multicenter Study.

American journal of medical genetics. Part A·2026
Same author

ULTRASONOGRAPHY, SHEAR WAVE ELASTOGRAPHY AND LIVER HISTOLOGY FOR THE DIFFERENTIAL DIAGNOSIS BETWEEN BILIARY ATRESIA AND OTHER CAUSES OF CHOLESTASIS.

Arquivos de gastroenterologia·2026
Same author

Association of cumulative fluid balance trajectories with haemodynamics, inflammation, and long-term mortality in critically ill patients with circulatory failure: physiology before phenotyping. Comment on Br J Anaesth 2026; 136: 542-51.

British journal of anaesthesia·2026
Same journal

N-ethyl-pentedrone poisoning as a cause of serotonin syndrome and gastrointestinal bleeding: a case report and literature review.

Anaesthesiology intensive therapy·2026
Same journal

Central venous cannulation in critically ill patients: guidelines of the Polish Society of Anaesthesiology and Intensive Therapy.

Anaesthesiology intensive therapy·2026
Same journal

Failure of tracheal tube removal after surgery: a case report.

Anaesthesiology intensive therapy·2026
Same journal

Femoral artery cannulation for arterial pressure measurement in the intensive care unit: current evidence and description of the technique.

Anaesthesiology intensive therapy·2026
Same journal

Erratum to the article: Transcranial sonography: practical use in the intensive care unit. Authors: Aleksandra Baska, Krystian Sporysz-Janiec, Monika Figura, Paweł Andruszkiewicz, Mateusz Zawadka. Anaesthesiol Intensive Ther 2024; 56(5): 267-276. DOI: https://doi.org/10.5114/ait.2024.146640.

Anaesthesiology intensive therapy·2026
Same journal

Emergency surgery and post-STEMI dual antiplatelet therapy. Looking for the sweet spot.

Anaesthesiology intensive therapy·2026
See all related articles

Related Experiment Video

Updated: May 2, 2026

Rose Bengal Photothrombosis by Confocal Optical Imaging In Vivo: A Model of Single Vessel Stroke
08:07

Rose Bengal Photothrombosis by Confocal Optical Imaging In Vivo: A Model of Single Vessel Stroke

Published on: June 23, 2015

15.3K

The ROSE framework for fluid therapy in critically ill pediatric patients.

Romina Aparecida Dos Santos Gomes1,2, Manu L N G Malbrain3,4,5, Adriana Teixeira Rodrigues1,2

  • 1Department of Pediatrics, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.

Anaesthesiology Intensive Therapy
|March 4, 2026
PubMed
Summary
This summary is machine-generated.

The ROSE framework is applicable for pediatric fluid management, showing feasibility and potential for individualizing care. While fluid accumulation was similar, adherence improved post-training.

Keywords:
ROSEchildrencritically illevacuationfluid accumulationfluid therapyoptimizationresuscitationstabilization

More Related Videos

Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE
03:22

Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE

Published on: March 1, 2024

1.4K
Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats
04:12

Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats

Published on: March 28, 2025

717

Related Experiment Videos

Last Updated: May 2, 2026

Rose Bengal Photothrombosis by Confocal Optical Imaging In Vivo: A Model of Single Vessel Stroke
08:07

Rose Bengal Photothrombosis by Confocal Optical Imaging In Vivo: A Model of Single Vessel Stroke

Published on: June 23, 2015

15.3K
Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE
03:22

Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE

Published on: March 1, 2024

1.4K
Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats
04:12

Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats

Published on: March 28, 2025

717

Area of Science:

  • Pediatric Critical Care Medicine
  • Fluid Management Strategies
  • Clinical Framework Implementation

Background:

  • Critically ill children often experience fluid overload, impacting outcomes.
  • The Resuscitation, Optimization, Stabilization, Evacuation (ROSE) framework offers a structured approach to fluid therapy.
  • Assessing the ROSE framework's applicability in pediatric intensive care is crucial.

Purpose of the Study:

  • To evaluate the feasibility and impact of the ROSE framework on fluid management in critically ill pediatric patients.
  • To assess the framework's effectiveness in preventing fluid accumulation and improving clinical outcomes.
  • To benchmark fluid accumulation percentages (FA%) across different phases of the ROSE framework.

Main Methods:

  • A quasi-experimental study comparing retrospective and prospective cohorts (n=122) of mechanically ventilated, vasoactive-dependent children.
  • Implementation of structured training on ROSE-guided fluid management for the prospective cohort.
  • Outcomes measured included fluid accumulation percentage (FA%), mechanical ventilation duration, PICU length of stay, and need for renal replacement therapy (RRT).

Main Results:

  • Fluid accumulation percentage (FA%) remained similar between retrospective and prospective cohorts across multiple time points.
  • FA% was comparable during Resuscitation, Optimization, and Evacuation phases, but higher during Stabilization in the prospective cohort.
  • Adherence to FA% targets increased from 67.9% to 72.4% after ROSE framework implementation; other clinical outcomes were similar.

Conclusions:

  • The ROSE framework is a feasible approach for managing fluid therapy in critically ill pediatric patients.
  • It provides valuable benchmarking for controlling fluid accumulation and shows promise for personalized fluid management.
  • Further validation in centers not previously exposed to the ROSE framework is recommended.