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Relentless placoid chorioretinitis associated with Crohn's disease and secondary MEWDS: a case report

Marion Sagnard1, Pierre Gascon1, Alban Comet1

  • 1Ophthalmology Department, Hopital Nord, Aix Marseille University, Marseille, France.

American Journal of Ophthalmology Case Reports
|March 4, 2026
PubMed
Abstract

Insights

This rare case study details relentless placoid chorioretinitis (RPC) in a patient with Crohn's disease, complicated by secondary multiple evanescent white dot syndrome (MEWDS). Anti-TNF therapy helped stabilize ocular inflammation, underscoring the link between these conditions.

Area of Science:

  • Ophthalmology
  • Gastroenterology
  • Immunology

Background:

  • Relentless placoid chorioretinitis (RPC) is a rare inflammatory condition affecting the choroid and retina.
  • Crohn's disease is a chronic inflammatory bowel disease with potential extraintestinal manifestations.
  • Co-occurrence of RPC and Crohn's disease suggests a potential autoimmune link.
Keywords:
Anti–TNF therapyCrohn's diseaseMultimodal imagingMultiple evanescent white dot syndromeRelentless placoid chorioretinitisUveitis

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