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Stepwise Depletion of CD27+IgD+ B Cells Correlates With Fibrosis Progression to Cirrhosis in HBV-Infected Patients

Jinwei Wu1, Cailing Wei1, Yaqin Qin1

  • 1The Fourth People's Hospital of Nanning, Guangxi, China.

Journal of Clinical and Experimental Hepatology
|March 4, 2026
PubMed

Insights

Peripheral CD27+IgD+B cells decrease with Hepatitis B Virus (HBV)-related liver fibrosis progression. These cells may serve as a non-invasive marker for monitoring fibrosis, with gender-specific associations in early stages.

Area of Science:

  • Immunology
  • Hepatology
  • Virology

Background:

  • Hepatitis B Virus (HBV) infection can lead to liver cirrhosis.
  • CD27+IgD+B cells are known to be depleted in HBV-related cirrhosis.
  • The dynamics of these cells during early fibrosis progression and their gender-specific associations are not well understood.

Purpose of the Study:

  • To investigate peripheral CD27+IgD+B cells in chronic HBV-infected patients across different fibrosis stages.
  • To analyze the associations of these cells with clinical indicators of liver disease.
  • To explore gender-specific correlations and longitudinal changes in CD27+IgD+B cell populations.

Main Methods:

  • Cross-sectional and retrospective study design.
  • Stratification of chronic HBV-infected patients based on liver fibrosis progression.
  • Flow cytometry analysis of CD27+IgD+B cells and correlation with clinical parameters (e.g., FIB-4, spleen size, total bile acid, platelet count, cholinesterase).

Main Results:

  • CD27+IgD+B cells showed a stepwise depletion with increasing fibrosis severity (from healthy controls to HBV, HBV-LC, and HBV-LC with HCC).
  • Cell levels correlated negatively with FIB-4 scores and positively with platelet counts and cholinesterase in cirrhotic patients.
  • Longitudinal analysis indicated stability in HBV patients, but a decline in CD27+IgD+B cells in most HBV-LC patients over time.

Conclusions:

  • Peripheral CD27+IgD+B cells are significantly associated with HBV-related liver fibrosis progression.
  • Gender-specific correlations were observed in the early stages of fibrosis.
  • The dynamic changes in these cells reflect fibrosis severity and splenic function, suggesting their potential as a non-invasive marker for early fibrosis monitoring.
Abstract

Keywords:
CD27+IgD+ B cellschronic HBV infectioncirrhosisflow cytometryliver fibrosis

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