Related Experiment Video
Updated: May 6, 2026
07:17
Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
Published on: June 22, 2016
9.5K
Distinct Antibody Fc-profiles in Lymph During Homeostasis and Chronic HIV Infection
Ryan P McNamara1, Audrey L Butler1, Sepideh Dolatshahi1,2
1Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts.
Pathogens & Immunity
|March 4, 2026
Summary
Antibody transfer from blood to lymph differs in people with HIV, with reduced IgG transfer impacting tissue access. This Fc-receptor dependent process influences antibody selection in inflammatory conditions.
Area of Science:
- Immunology
- Pathogen Control
- Tumor Surveillance
Background:
- Antibodies are crucial for immune defense against pathogens and tumors.
- Antibodies circulate between blood, lymph, and tissues.
- Antibody composition may vary across different body compartments.
Purpose of the Study:
- To investigate antibody profiles in blood versus lymph.
- To understand antibody transfer properties between compartments.
- To identify differences in antibody transfer in disease states.
Main Methods:
- Antibody profiling of chyle (lymph) and matched plasma samples.
- Comparison of pathogen-specific IgG levels and functions.
- Analysis of antibody transfer ratios.
Main Results:
- In healthy individuals, IgG levels and functions were similar in plasma and lymph.
- In people with HIV, IgG transfer to lymph was significantly reduced for certain antibodies.
- Differential IgG transfer was dependent on Fc-receptor interactions.
Conclusions:
- Fc-receptor interactions mediate IgG transfer into tissues.
- Inflammatory conditions can alter antibody selection for tissue access.
- Understanding antibody transfer is key to immune defense mechanisms.
Related Concept Videos
01:36Humoral Immune Responses
66.4K
Overview
66.4K
01:41Affinity and Avidity
35.5K
Overview
35.5K
01:20Special Features of Adaptive Immunity
3.7K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
3.7K
01:24B Cell Activation and Differentiation
14.6K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
14.6K
01:25Antibody Structure and Classes
7.7K
Antibodies, also known as immunoglobulins, are produced by B cells in response to foreign substances, such as bacteria and viruses. These proteins are critical for recognizing and neutralizing these substances, protecting the body from potential harm.
The basic structure of an antibody consists of four protein chains: two identical heavy chains and two identical light chains. These chains are held together by disulfide bonds and other non-covalent interactions, forming a Y-shaped structure.
The basic structure of an antibody consists of four protein chains: two identical heavy chains and two identical light chains. These chains are held together by disulfide bonds and other non-covalent interactions, forming a Y-shaped structure.
7.7K
01:29Immune Response Against Viral Pathogens
2.4K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
2.4K