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Published on: November 30, 2021
Necrotizing Enterocolitis in Term Neonates: A Retrospective Chart Review from Children's Medical Center, Tehran
Kayvan Mirnia1, Maryam Saeedi1, Amir Ali Ahrabi2
1Children's Medical Center, Pediatric Center of Excellence, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Archives of Iranian Medicine
|March 4, 2026
Summary
Necrotizing enterocolitis (NEC) affects term neonates, with a 3.38% incidence in this study. Herbal medication intake was a potential risk factor, emphasizing the need for culturally sensitive prevention strategies.
Area of Science:
- Neonatal Medicine
- Pediatric Gastroenterology
- Clinical Pediatrics
Background:
- Necrotizing enterocolitis (NEC) is a critical condition in neonatal intensive care units (NICUs).
- While prematurity is a known risk factor, NEC also affects full-term neonates.
- This study focuses on NEC in term infants at a tertiary hospital in Tehran, Iran.
Purpose of the Study:
- To investigate the incidence of NEC in term neonates.
- To describe the clinical presentation and associated medical conditions of NEC in term infants.
- To identify potential risk factors for NEC in this population.
Main Methods:
- Retrospective review of term neonates diagnosed with NEC between 2020 and 2023.
- Data collection included demographics, clinical signs, lab results, comorbidities, treatments, and outcomes.
- Comparison with non-NEC term neonates to identify risk factors.
Main Results:
- An incidence of 3.38% for NEC was observed in term neonates.
- Abdominal distention was the most frequent initial symptom (78.8%).
- Herbal medication intake was significantly higher in NEC cases (P=0.02); no mortality was recorded.
Conclusions:
- NEC occurs with notable frequency in term neonates at a tertiary Iranian NICU.
- Herbal medication use emerged as a potential risk factor for NEC in term infants.
- Early recognition and culturally sensitive prevention are crucial, particularly in regions with prevalent herbal remedy use.
