Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Study Designs in Epidemiology01:20

Study Designs in Epidemiology

1.3K
Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
1.3K
Clinical Trials: Overview01:11

Clinical Trials: Overview

5.2K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
5.2K
Clinical Trials01:16

Clinical Trials

11.0K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
11.0K
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

195
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
195
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

510
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
510
Study Design in Statistics01:15

Study Design in Statistics

10.1K
A study design is a set of techniques that allow a researcher to collect and analyze data from different variables defined for a specific research problem. Statistics is commonly for effective study design and more robust experiments,
Does aspirin reduce the risk of heart attacks? Is one brand of fertilizer more effective at growing roses than another? Is fatigue as dangerous to a driver as the influence of alcohol? Questions like these are answered using randomized experiments with proper...
10.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ENTF Neuromodulation Yields Reduced Disability After Stroke: An Individual Participant-Level Data Meta-Analysis.

Stroke·2026
Same author

N-Acetylcysteine protects the developing brain in neonatal sepsis-like inflammation via a redox-neurovascular pathway.

Journal of neuroinflammation·2026
Same author

Thrombectomy in Posterior Circulation Tandem Occlusions: Multicenter Comparative Analysis of Procedural Techniques and Predictors of Clinical Outcomes.

Radiology·2026
Same author

Advances in Acute Ischemic Stroke 2025: Medical Treatments.

Stroke·2026
Same author

Faster reperfusion with combined delivery catheter systems in aspiration-first stroke thrombectomy: a multicenter analysis.

Journal of neurointerventional surgery·2026
Same author

Efficacy and safety of early tirofiban administration after intravenous thrombolysis in patients with acute ischaemic stroke: the multicentre, randomised, double-blind, placebo-controlled RESCUE BT3 trial protocol.

European stroke journal·2026
Same journal

Long-Term Outcomes of Glucagon-Like Peptide-1 Receptor Agonists in Patients With Peripheral Artery Disease and Type 2 Diabetes.

Journal of the American Heart Association·2026
Same journal

Stable, Progressive, and Acute Valve Syndrome in Severe Aortic Stenosis: Insights from the CURRENT AS Registry-2.

Journal of the American Heart Association·2026
Same journal

<i>LPA</i> Kringle IV Type-2 Genetic Variants Are Associated With Apolipoprotein (a) Size, Hypertension, and Nonfasting Glucose Levels.

Journal of the American Heart Association·2026
Same journal

Hemorrhagic Transformation Mediates Stress Hyperglycemia Effect on Functional Outcome in Minor Ischemic Stroke.

Journal of the American Heart Association·2026
Same journal

Mental Disorders After Cardiac Implantable Electronic Device Implantation in Young Individuals.

Journal of the American Heart Association·2026
Same journal

Hypertensive Disorders of Pregnancy Associated With Cerebral Small Vessel Disease Decades Later.

Journal of the American Heart Association·2026
See all related articles

Related Experiment Video

Updated: Mar 6, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

11.4K

ADJUVANT Randomized Controlled Trial: Rationale and Design.

Hongfei Sang1,2, Zhilin Zheng1, Heng Ni1

  • 1Department of Neurology, Affiliated Hangzhou First People's Hospital Westlake University School of Medicine Hangzhou China.

Journal of the American Heart Association
|March 4, 2026
PubMed
Summary
This summary is machine-generated.

This study compares intravenous tirofiban with standard thrombolysis as a bridge to endovascular thrombectomy (EVT) for acute ischemic stroke. It investigates if tirofiban is a viable alternative to thrombolysis in EVT procedures for large-vessel occlusion.

Keywords:
endovascular thrombectomyintravenous thrombolysisischemic strokeprotocolrandomized trialtirofiban

More Related Videos

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

1.3K
E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
06:28

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

Published on: August 1, 2019

9.3K

Related Experiment Videos

Last Updated: Mar 6, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

11.4K
Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

1.3K
E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
06:28

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

Published on: August 1, 2019

9.3K

Area of Science:

  • Neurology
  • Cardiology
  • Clinical Trials

Background:

  • Endovascular thrombectomy (EVT) with intravenous thrombolysis is standard for acute ischemic stroke from large-vessel occlusion.
  • Glycoprotein IIb/IIIa inhibitors like tirofiban are explored for thrombosis management.
  • The efficacy of tirofiban as an alternative to thrombolysis before EVT is not well-established.

Purpose of the Study:

  • To assess if intravenous tirofiban plus EVT is noninferior to intravenous thrombolysis bridging with EVT.
  • To evaluate tirofiban as an alternative adjuvant therapy in acute ischemic stroke patients eligible for thrombolysis.

Main Methods:

  • The ADJUVANT trial is a multicenter, randomized, open-label, noninferiority study.
  • 976 thrombolysis-eligible stroke patients with large-vessel occlusion will be randomized 2:1.
  • Participants receive either intravenous tirofiban + EVT or intravenous thrombolysis + EVT.

Main Results:

  • The primary efficacy outcome is functional independence (modified Rankin scale 0-2) at 90 days.
  • Key safety outcomes include symptomatic intracranial hemorrhage and 90-day mortality.

Conclusions:

  • The ADJUVANT trial will offer critical data on tirofiban's efficacy and safety.
  • Findings will inform treatment strategies for acute ischemic stroke patients undergoing EVT.