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Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16
Published on: July 15, 2019
Nowarta110 Displays Antiviral Properties Against Coxsackievirus B and Herpes Simplex Virus 2
Jon Sin1, Hong-An Tran2, Thanh X Hoang2
1Department of Biological Sciences, University of Texas at Dallas, Texas, USA.
Abstract:
Nowarta110 is a novel fig extract and colloidal silver therapeutic composition initially designed to treat plantar warts caused by human papilloma virus (HPV). In a recent study, we also demonstrated that our nutraceutical formulation exhibits potent antitumoral activity in mice xenografted with HPV-transformed cells. Fig extracts have been shown to provide antiviral effects toward a number of viruses; thus, to explore Nowarta110's potential antiviral activity, we evaluated its impact on in vitro models of both Coxsackievirus B (CVB) and herpes simplex virus type 2 infections. We found that Nowarta110 significantly reduced infection of human cells with both CVB and herpes simplex virus 2. In all, these findings demonstrate that Nowarta110 possesses antiviral properties against a broad range of viruses. Thus, further studies interrogating its antiviral therapeutic potential are warranted.
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