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Managing Fever and Vaccination Risks in Dravet Syndrome: From Pathophysiology to Clinical Practice.

Alessandro Ferretti¹, Marco Bianchi¹, Mattia Costa¹

¹Pediatrics Unit, Neuroscience, Mental Health and Sense Organs (NESMOS) Department, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy.

Journal of Child Neurology

|March 4, 2026

Summary

Fever management in Dravet syndrome (DS) requires aggressive pyrexia control and proactive strategies for hyperthermia. Vaccinations are recommended for children with DS, with prophylactic antipyretics to mitigate seizure risks.

Keywords:

Dravet syndrome children fever management vaccine

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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

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Area of Science:

Neurology
Genetics
Pediatrics

Background:

Dravet syndrome (DS) is a severe epileptic encephalopathy often caused by SCN1A mutations.
Thermosensitivity and hyperthermia are potent seizure triggers in DS patients.

Purpose of the Study:

To review evidence-based strategies and expert consensus for managing fever and hyperthermia in children with DS.
To provide guidance on vaccination management in DS, addressing seizure risks.

Main Methods:

Literature synthesis of evidence-based strategies.
Incorporation of expert consensus on fever and hyperthermia management.
Review of vaccination guidelines and associated risks in DS.

Main Results:

Aggressive fever control is recommended, including early antipyretics, physical cooling, and prophylactic benzodiazepines.
Proactive management of non-febrile hyperthermia triggers is crucial.
Vaccinations are safe and recommended for DS patients, with prophylactic antipyretics advised.

Conclusions:

Current DS fever and hyperthermia management relies heavily on expert consensus.
Further clinical trials are needed to bridge the gap between consensus and evidence.
Optimized management strategies are essential for reducing morbidity and improving quality of life in DS.