Related Experiment Video
Updated: Mar 6, 2026
10:25
Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
Published on: December 12, 2019
8.2K
Interactions between Notch and MAPK signaling in neurovascular development: Implications for advanced disease
Hanna Kuźmińska1,2, Dries Braeken1, Liesbet Lagae1,2
1imec, Leuven, Belgium.
Neural Regeneration Research
|March 4, 2026
Summary
The Notch and Mitogen-activated Protein Kinase pathways are crucial for neurovascular development and regeneration. Understanding their complex interplay offers new therapeutic strategies for neurological disorders.
Area of Science:
- Neurobiology
- Developmental Biology
- Vascular Biology
Background:
- Neurovascular development requires precise coordination between the central nervous system and its vascular network.
- Cellular crosstalk guides blood vessel invasion into neural tissues, establishing the blood-brain barrier and regulating cerebral blood flow.
Purpose of the Study:
- To synthesize current understanding of Notch and Mitogen-activated Protein Kinase (MAPK) pathways in neurovascular development and regeneration.
- To explore the molecular mechanisms and complex interplay between these signaling pathways.
Main Methods:
- Review of existing literature on Notch and MAPK signaling in neurovascular biology.
- Analysis of cooperative and antagonistic interactions between signaling cascades.
- Examination of crosstalk with Wnt and Hedgehog pathways.
Main Results:
- Notch and MAPK pathways are central regulators of cell communication, differentiation, and morphogenesis during neurovascular development.
- Their interactions are critical for normal development and pathological processes.
- These pathways are modulated by feedback mechanisms and crosstalk with other signaling networks.
Conclusions:
- Elucidating the integrated roles of Notch and MAPK signaling deepens understanding of developmental neurobiology.
- Targeting the interplay between these pathways offers promising avenues for disease models and regenerative therapies.
- This approach presents a compelling strategy for neurovascular disorder treatment and tissue engineering.
Related Concept Videos
03:14Notch Signaling Pathway
6.7K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.7K
01:12Role Of Notch Signalling In Intestinal Stem Cell Renewal
2.5K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.5K
01:24Regulation of Angiogenesis and Blood Supply
3.8K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
3.8K
01:07MAPK Signaling Cascades
8.9K
Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
8.9K
01:10Mechanism of Angiogenesis
7.3K
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
7.3K
01:24Overview of Cell-Matrix Interactions
9.5K
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
9.5K