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Updated: Jun 5, 2026

Behavioral Assessment of Manual Dexterity in Non-Human Primates

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Published on: November 11, 2011

Dynamic structural connectivity changes in cortical and cortico-striatal strokes in mice.

Fatemeh Mahani^1,2, Aref Kalantari², Michael Diedenhofen³

¹Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Centre Juelich, Juelich, Germany.

Neural Regeneration Research

|March 4, 2026

Summary

Stroke severity significantly impacts brain connectivity changes. Larger lesions increase sensorimotor connectivity, while smaller ones cause asymmetric disruptions, highlighting the need for tailored monitoring post-stroke.

Keywords:

brain network degeneration diffusion MRI fiber tracking longitudinal middle cerebral artery occlusion mouse photothrombosis rodent white matter plasticity

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Last Updated: Jun 5, 2026

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Neurobehavioral Assessments in a Mouse Model of Neonatal Hypoxic-ischemic Brain Injury

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Area of Science:

Neuroscience
Neuroimaging
Stroke Research

Background:

Stroke causes widespread brain alterations beyond initial damage.
The impact of stroke lesion size and location on white matter changes and plasticity is not fully understood.

Purpose of the Study:

To investigate how different stroke models (lesion size and topology) affect white matter changes over time.
To compare structural connectivity dynamics in response to varying stroke severities.

Main Methods:

Utilized repetitive diffusion magnetic resonance imaging in mice over 4 weeks post-stroke.
Compared photothrombotic cortical (small) and middle cerebral artery occlusion (large) stroke models.
Quantified whole-brain structural connectivity changes, including inter- and intra-hemispheric seed strength.

Main Results:

Large cortico-striatal lesions increased structural connectivity in sensorimotor areas.
Small cortical lesions resulted in asymmetric connectivity changes: increased from the ischemic hemisphere and decreased from the healthy hemisphere.
Stroke severity and lesion size significantly influenced the timing and spatial patterns of connectivity disruptions.

Conclusions:

Stroke-induced white matter alterations are dependent on lesion characteristics.
Findings emphasize the need for monitoring neural changes tailored to stroke severity and lesion profile.
This study provides insights into the brain's structural response to stroke, informing recovery and rehabilitation strategies.