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Patients may not prioritize treatment mode or frequency, but often prefer oral administration. Less severe disease or treatment experience can influence preferences for oral routes over injections.

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Area of Science:

  • Health Services Research
  • Patient-Reported Outcomes
  • Medical Product Development

Background:

  • Patient preference studies identify key aspects of medical products.
  • Understanding patient preferences for treatment processes is crucial for product development and adherence.

Purpose of the Study:

  • To summarize patient preferences regarding treatment process attributes, specifically mode and frequency.
  • To analyze how patient characteristics influence preferences for different treatment modes and frequencies.

Main Methods:

  • Systematic review of English-language, peer-reviewed studies quantitatively eliciting patient preferences for treatment mode and frequency.
  • Searches conducted across multiple databases (MEDLINE, Embase, Scopus, EconLit, Health Preference Research) and reference lists.
  • Study quality assessed using the PREFS checklist; data extracted by two independent reviewers.

Main Results:

  • 164 studies were included, with a mean quality score of 3.48/5 on the PREFS checklist.
  • Mode and frequency attributes were often not ranked among the top two patient preferences.
  • Oral administration was the most preferred mode when offered; patients with milder disease or less treatment experience favored oral over injected treatments.

Conclusions:

  • While mode/frequency may not be primary concerns, specific patient groups show strong preferences, particularly for oral treatments.
  • High study quality was noted, but patient engagement in research was limited and needs improvement.
  • Future research should involve deeper patient engagement throughout the research lifecycle, aligning with ISPOR definitions.