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A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
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Clinical and Pathologic Factors in Stage I and II Melanoma Recurrence
Maya Mundada1, Xiaochen Zhong1, Alexandra So1
1School of Medicine, University of California, San Francisco.
JAMA Dermatology
|March 4, 2026
Summary
Factors beyond melanoma thickness and ulceration, including tumor location and mitoses, significantly predict recurrence risk in localized melanomas. This information aids in patient surveillance and counseling for melanoma recurrence.
Area of Science:
- Oncology
- Dermatology
- Cancer Research
Background:
- Localized melanomas represent a significant cause of cancer mortality.
- Few studies have investigated factors predicting recurrence risk in localized melanomas.
Purpose of the Study:
- To identify clinical and pathological factors associated with melanoma recurrence risk in localized (stage IA-IIC) melanomas.
Main Methods:
- Analysis of data from 1092 patients diagnosed with localized melanomas between 2010 and 2017.
- Multivariable analysis to identify significant predictors of time to melanoma recurrence.
Main Results:
- Melanoma ulceration, thickness, tumor location (scalp/neck, face), neurotropism, lymphovascular invasion, and mitoses were significantly associated with increased recurrence risk.
- Hazard ratios ranged from 1.09 for thickness to 3.93 for mitoses.
Conclusions:
- Factors beyond current staging criteria (thickness, ulceration) are associated with localized melanoma recurrence.
- These additional factors can enhance patient surveillance and counseling strategies for melanoma.
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