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Related Experiment Video

Updated: Mar 6, 2026

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Combining transcranial direct current stimulation and computerized cognitive training for post-stroke cognitive

Xinling Wei1, Jianwei Xia2, Rui Luo3

  • 1Rehabilitation College, Gannan Medical University, Jiangxi, China.

Plos One
|March 4, 2026
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Summary

This study compares different timings for transcranial direct current stimulation (tDCS) and computerized cognitive training (CCT) to improve post-stroke cognitive impairment (PSCI). Findings will guide optimal clinical strategies for stroke rehabilitation.

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Area of Science:

  • Neuroscience
  • Rehabilitation Medicine
  • Cognitive Science

Background:

  • Post-stroke cognitive impairment (PSCI) is a significant complication affecting daily life and rehabilitation.
  • Current treatments combining transcranial direct current stimulation (tDCS) and computerized cognitive training (CCT) have limitations in protocol optimization.
  • Systematic comparison of sequential tDCS and CCT strategies is lacking to determine optimal clinical approaches.

Purpose of the Study:

  • To compare sequential intervention strategies of tDCS and CCT in patients with PSCI.
  • To identify the optimal timing for combining tDCS and CCT for improved cognitive function.
  • To address the research gap in optimizing clinical protocols for PSCI.

Main Methods:

  • A single-center, double-blind, randomized controlled trial involving 60 patients with PSCI.
  • Four groups: three intervention groups (tDCS pre-training, concurrent, or post-training with CCT) and one sham control group.
  • Interventions administered five times/week for two weeks, with follow-ups at 4 and 12 weeks post-intervention.

Main Results:

  • This trial aims to systematically evaluate the optimal timing for combining tDCS and CCT in PSCI.
  • Hypothesized mechanisms include enhanced cognitive processing, promoted plasticity, and consolidated training effects.
  • Cerebral oxygenation parameters will assess microcirculatory improvements linked to cognitive recovery.

Conclusions:

  • The study will provide insights into the optimal timing of tDCS and CCT for PSCI.
  • Potential limitations include ceiling effects, test biases, sample size, and lack of lesion stratification.
  • Future research should incorporate multimodal neuroimaging and personalized interventions for advanced precision rehabilitation.