Related Experiment Video

Updated: Mar 6, 2026

Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells
05:45

Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells

Published on: October 10, 2025

593

Management of Nail Toxicities From Fibroblast Growth Factor Receptor Inhibitors

Aneri Bhargav Patel, Xiying Fan, Janellen Smith

    Journal of Drugs in Dermatology : JDD
    |March 4, 2026
    PubMed
    Abstract

    Insights

    Fibroblast growth factor receptor inhibitors (FGFRi) can cause nail toxicities in cancer patients. Management strategies are available, but further research is needed for prevention and optimized care.

    Area of Science:

    • Oncology
    • Pharmacology
    • Dermatology

    Background:

    • Fibroblast growth factor receptor (FGFR) signaling alterations are implicated in various cancers.
    • FGFR inhibitors (FGFRi) are increasingly used for treating urothelial carcinoma, cholangiocarcinoma, and gastrointestinal cancers.
    • Nail toxicities (e.g., onycholysis, paronychia) are an underrecognized adverse effect of FGFRi.

    Purpose of the Study:

    • To systematically review and characterize FGFR inhibitor-associated nail disorders.
    • To analyze the incidence, severity, onset, and management of FGFRi-related nail toxicities.
    • To identify needs for future research in FGFRi-induced nail complications.

    Main Methods:

    • Systematic literature review of PubMed and Google up to March 2025.
    • Inclusion of case reports, trials, and retrospective studies on FGFRi and nail adverse events.
    • Extraction of data on incidence, severity (CTCAE v5.0), onset, management, and treatment impact; statistical analysis using Wilcoxon and Chi-square tests.

    Main Results:

    • Analysis of 23 studies involving 1,561 patients; 540 experienced nail toxicity.
    • Highest nail toxicity rate with erdafitinib (43.3%), lowest with derazantinib (5.3%).
    • Grade 1-2 events were most common; Grade 3 events led to dose reduction in 3/540 patients; no treatment discontinuations reported. Management included antiseptic soaks, topical steroids, oral antibiotics, and protective nail care.

    Conclusions:

    • FGFRi-associated nail toxicities vary by agent, impacting quality of life and treatment adherence.
    • Pathogenesis and predictive biomarkers for FGFRi nail toxicity remain unclear.
    • Optimized management and preventative strategies require further research; early recognition and multidisciplinary care are essential.

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