Transitioning from Anti-aging to Skin Activation: Limiting Cellular Fatigue and Senescence for Skin Longevity

Skin thinning, known as dermatoporosis, is an expected consequence of aging that involves structural weaknesses, barrier deficiencies, and cellular senescence, posing challenges for maintaining long-term skin health.

To introduce Skin Activation as a dermatologic strategy for promoting skin longevity. It is supported by clinical and preclinical evidence, combining methods to remodel the extracellular matrix (ECM) and dermo-epidermal junction (DEJ), restore the barrier, and enhance hydration, along with reducing senescent cells. This improves the skin's functional resilience.

Data were generated from a multicenter dermatoporosis trial, a randomized controlled trial, and specific cohorts of sensitive skin patients, in addition to preclinical studies. Study endpoints included trans-epidermal water loss (TEWL), hydration levels, LC-Optical Coherence Tomography (LC-OCT), assessments of the DEJ, ultrasound measurements, senescent markers, and histology. The data also included measures of senescence, cytokine profiles, and biomarkers of cellular renewal.

Among 400 participants, notable changes included a 20-40% reduction in TEWL, an 80% increase in hydration based on corneometer readings, a 5% rise in skin thickness, and improved DEJ integrity in 83% of subjects compared to 17% of controls. In preclinical ex vivo models, decreases in fibroblast senescence levels were observed, along with activation of the JAG/NOTCH pathway.

A recently developed skin activator program shifts dermatologic skin health strategies from a broad anti-aging focus to a more targeted skin activation approach focused on structure, function, and cellular energy and renewal. This reinforces the ongoing commitment to dermatological innovation and establishes a more structured approach to skin longevity.  .