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Related Experiment Video

Updated: Mar 6, 2026

Decellularization of Whole Human Heart Inside a Pressurized Pouch in an Inverted Orientation

Decellularization of Whole Human Heart Inside a Pressurized Pouch in an Inverted Orientation

Published on: November 26, 2018

Tissue compliance characterization for human umbilical arteries after decellularization.

Kun Gou¹, Jin-Jia Hu², Seungik Baek³

¹Department of Computational, Engineering, and Mathematical Sciences, Texas A&M University-San Antonio, San Antonio, TX, USA.

Journal of the Mechanical Behavior of Biomedical Materials

|March 4, 2026

Summary

Decellularization of human umbilical arteries (HUAs) for vascular grafts slightly decreases compliance. Stored strain energy better reflects mechanical changes than compliance during graft preparation.

Keywords:

Decellularization Parameter fitting Tissue damage Umbilical artery Vascular graft

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Last Updated: Mar 6, 2026

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Comparable Decellularization of Fetal and Adult Cardiac Tissue Explants as 3D-like Platforms for In Vitro Studies

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Published on: June 9, 2022

Area of Science:

Biomaterials Science
Vascular Tissue Engineering
Biomedical Engineering

Background:

Human umbilical arteries (HUAs) are suitable for small-diameter vascular grafts due to their native mechanical properties.
Decellularization of HUAs is necessary to reduce immunogenicity and improve host tissue integration.
Understanding mechanical changes in decellularized HUAs (Dec-HUAs) is crucial for graft compatibility.

Purpose of the Study:

To characterize mechanical alterations in HUAs after decellularization.
To evaluate the effectiveness of a hyperelastic damage model in assessing these changes.
To compare the sensitivity of different mechanical indices to decellularization-induced modifications.

Main Methods:

Mechanical characterization of five HUA samples after abluminal layer removal and decellularization.
Modeling mechanical response using a modified hyperelastic damage framework with isotropic and anisotropic parameters.
Parameter estimation via an improved fitting approach and statistical analysis of mechanical properties.

Main Results:

Decellularized HUAs (Dec-HUAs) exhibited reduced compliance compared to native HUAs.
Abluminal layer removal increased compliance, while decellularization caused a mild decrease.
Stored strain energy (W) was a more sensitive indicator of compliance changes than compliance (C) during graft preparation.

Conclusions:

Decellularization induces significant, albeit mild, alterations in the mechanical properties of HUAs.
The developed hyperelastic damage framework provides a robust method for assessing vessel mechanics.
This framework supports the development of mechanically compatible and durable vascular grafts.