Related Experiment Video
Updated: Mar 6, 2026

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
Published on: July 20, 2019
Regulatory T cells thrive in ammonia-rich tumors
Chenxian Ye1, Greg M Delgoffe1
1Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Abstract:
In a recent issue of Cell, Gu et al. find that regulatory T (Treg) cells metabolize tumor-derived ammonia via the urea cycle and spermine synthesis, promoting immunosuppression through PPARγ-dependent oxidative phosphorylation. Inhibition of tumor glutamine metabolism reduces ammonia levels and overcomes Treg cell-mediated resistance to anti-PD-1 therapy.
More Related Videos
07:17Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
Published on: June 22, 2016
07:36Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
Published on: June 12, 2021
Related Concept Videos
Tumor Immunotherapy
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
The Tumor Microenvironment