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Related Concept Videos

Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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The factors influencing the health-illness continuum can be internal or external and may or may not be under conscious control. They are related to the following eight human dimensions, and each dimension is interrelated to one other.
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Related Experiment Video

Updated: Mar 6, 2026

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
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Resilience-based longevity medicine: A multiscale and dynamic integrative framework.

Mathias Schlögl1, Vincenza Frisardi2, Luigi Marano3

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Summary
This summary is machine-generated.

Population ageing increases the gap between lifespan and healthspan. This review reframes resilience as a dynamic, multilevel construct to preserve adaptive capacity and functional independence in older adults.

Keywords:
Allostatic loadBiomarkersDigital phenotypingFrailtyGeroscienceIntrinsic capacityResilience

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Area of Science:

  • Gerontology and Longevity Science
  • Biomedical Engineering
  • Public Health Policy

Background:

  • Population ageing is widening the gap between lifespan and healthspan, leading to increased frailty and functional dependence in older adults.
  • Individual aging trajectories are heterogeneous, indicating that vulnerability is influenced by adaptive capacity rather than chronological age alone.
  • Current approaches often focus on disease-centered care, neglecting the preservation of adaptive capacity.

Purpose of the Study:

  • To reframe resilience as a dynamic, multilevel construct.
  • To synthesize evidence for operational resilience readouts.
  • To propose an integrated longevity medicine framework for clinical application.

Main Methods:

  • Review of existing literature on population ageing, healthspan, and resilience.
  • Synthesis of evidence linking molecular maintenance, immune-endocrine-autonomic regulation, and functional trajectories (WHO Intrinsic Capacity framework).
  • Identification of operational resilience readouts based on recovery dynamics, physiological flexibility, and integrated biomarker profiles (multi-omics, autonomic/endocrine rhythms, digital measures, functional performance).

Main Results:

  • Resilience is a multilevel construct involving molecular, physiological (vital systems triad), and functional domains.
  • Measurable resilience signatures can be derived from recovery dynamics, physiological flexibility, and integrated biomarkers.
  • Lifestyle, psychosocial, and pharmacological strategies impact shared resilience pathways.

Conclusions:

  • Resilience is a modifiable target that can shift ageing strategies from disease-centered care toward preserving adaptive capacity.
  • An integrated longevity medicine framework can embed resilience assessment into clinical decision-making, predictive modeling, and policy.
  • Focusing on resilience promotes functional independence and meaningful engagement throughout the life course.