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Central Precocious Puberty and Optic Pathway Glioma in Children with Neurofibromatosis 1: Associations with Tumor
Julia Katz1, Ethan Hillis2, Jenny P Garzon3
1Department of Pediatrics, St. Louis Children's Hospital and Washington University, St. Louis, MO.
The Journal of Pediatrics
|March 4, 2026
Abstract:
Neurofibromatosis 1-associated optic pathway gliomas (OPGs) may co-occur with central precocious puberty (CPP). Using large language model-based data analysis from 2 NF centers, we compared OPGs in children with NF1, with and without CPP. CPP was associated with hypothalamic involvement, poorer vision, and a higher likelihood of OPG treatment.

