Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

2.5K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
2.5K
Nociception01:44

Nociception

33.5K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
33.5K
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists01:30

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

765
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
765
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

447
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
447
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

2.0K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
2.0K
Cognitive Therapy01:25

Cognitive Therapy

1.4K
Cognitive therapy, pioneered by Aaron T. Beck in the 1960s, is a structured approach to addressing psychological distress by focusing on the influence of thoughts on emotions and behaviors. All cognitive therapies involve the basic assumption that human beings have control over their feelings, and that how individuals feel about something depends on how they think about it. Unlike psychoanalytic methods that delve into unconscious processes or humanistic approaches emphasizing...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lipidomics reveals TREM2-associated dysregulation of plasma lipid metabolism in Alzheimer's disease.

Journal of Alzheimer's disease : JAD·2026
Same author

Associations of social isolation and loneliness with neurological disorders, psychiatric disorders, brain structures and behavioural phenotypes among UK Biobank participants.

Nature communications·2026
Same author

Associations of oral contraceptives and hormone replacement therapy with incident dementia risk: a population-based cohort study.

Translational psychiatry·2026
Same author

TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, leading to anxiety-like behaviors.

Journal of Alzheimer's disease : JAD·2026
Same author

Association between falls and dementia risk: Evidence from three cohort studies.

Journal of translational internal medicine·2025
Same author

MRPL37 promotes hepatocellular carcinoma progression through modulating mitochondrial energy metabolism.

iScience·2025

Related Experiment Video

Updated: Mar 6, 2026

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research
08:33

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research

Published on: January 5, 2024

1.9K

Chronic Pain and Cognitive Dysfunction: Clinical Implement, Mechanism, and Therapeutic Strategy.

Junjie Hu1, Pei-Yang Gao1, Run Di1

  • 1Department of Neurology & Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing 100053, China.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|March 4, 2026
PubMed
Summary
This summary is machine-generated.

Chronic pain significantly impacts cognitive function through neuroinflammation and neurotransmitter imbalances, affecting memory and attention. Understanding these links is crucial for developing targeted treatments for chronic pain and cognitive decline.

Keywords:
chronic paincognitive dysfunctionhippocampusneuroinflammationneurotransmitter dysregulationsynaptic plasticitytherapeutic strategies

More Related Videos

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
09:38

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Published on: April 14, 2016

13.3K
Intracranial Pharmacotherapy and Pain Assays in Rodents
02:26

Intracranial Pharmacotherapy and Pain Assays in Rodents

Published on: April 9, 2019

5.9K

Related Experiment Videos

Last Updated: Mar 6, 2026

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research
08:33

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research

Published on: January 5, 2024

1.9K
Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
09:38

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Published on: April 14, 2016

13.3K
Intracranial Pharmacotherapy and Pain Assays in Rodents
02:26

Intracranial Pharmacotherapy and Pain Assays in Rodents

Published on: April 9, 2019

5.9K

Area of Science:

  • Neuroscience
  • Pain Research
  • Cognitive Science

Background:

  • Chronic pain (CP) is increasingly linked to cognitive dysfunction.
  • Neurobiological mechanisms include neuroinflammation, neurotransmitter dysregulation, and impaired synaptic plasticity.
  • These effects are pronounced in brain regions vital for cognition, such as the hippocampus and medial prefrontal cortex (mPFC).

Purpose of the Study:

  • To review clinical and preclinical findings on chronic pain-related cognitive dysfunction.
  • To outline the key molecular mechanisms underlying this dysfunction.
  • To explore emerging therapeutic strategies for managing pain and cognitive impairment.

Main Methods:

  • Integration of clinical and preclinical research findings.
  • Analysis of neuroimaging studies in chronic pain patients.
  • Examination of molecular pathways involving cytokines and neurotrophic factors.

Main Results:

  • Chronic pain induces neuroinflammation (e.g., IL-1β, TNF-α) and neurotransmitter imbalances, impairing synaptic plasticity and neurogenesis.
  • Structural and connectivity changes in the hippocampus and mPFC are observed in chronic pain.
  • Brain-derived neurotrophic factor (BDNF) dysregulation contributes to cognitive decline.

Conclusions:

  • Chronic pain significantly contributes to cognitive dysfunction via neurobiological pathways.
  • These mechanisms are relevant to aging and Alzheimer's disease (AD), with CP potentially being a risk factor.
  • Targeting inflammation, neurotransmitter systems, and synaptic repair offers potential therapeutic avenues.