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Long-term thrombus-free left atrial appendage occlusion via magnetofluids
Shu Wang1, Wenhao Ju2, Donglin Zhuang2
1Guangdong Provincial Key Lab of Robotics and Intelligent System, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Nature
|March 4, 2026
Summary
A novel magnetofluid-based approach offers a personalized solution for left atrial appendage occlusion (LAAO), effectively preventing leaks and thrombus formation. This innovative method shows promising long-term safety and biocompatibility in preclinical studies.
Area of Science:
- Biomaterials Science
- Cardiovascular Engineering
- Medical Devices
Background:
- Current left atrial appendage occlusion (LAAO) methods face challenges with peri-device leaks and device-related thrombus.
- These issues stem from the incompatibility of solid occluders with diverse left atrial appendage (LAA) anatomies.
Purpose of the Study:
- To develop and evaluate a personalized LAAO strategy using magnetofluids.
- To assess the efficacy and safety of magnetofluids for complete and thrombus-free LAAO across all LAA types.
Main Methods:
- Magnetofluids were injected into LAAs via cardiac catheters and solidified into magnetogels upon contact with blood.
- The magnetogel's resistance to blood flow under magnetic fields was assessed.
- Long-term in vivo biocompatibility and efficacy were evaluated over 10 months in a porcine model.
Main Results:
- The magnetogel demonstrated long-term resilience and biocompatibility without observed thrombus or leakage in pigs.
- In contrast to the Watchman occluder, the magnetogel formed a smooth, firm, and thrombus-free surface against the LAA.
- No myocardial injury or interfacial crevices were observed with the magnetogel LAAO.
Conclusions:
- Magnetofluid-based LAAO presents a promising, personalized clinical strategy for achieving long-term thrombus-free occlusion.
- This approach overcomes limitations of current solid occluders, offering improved safety and efficacy for diverse LAA anatomies.
