Light-Programmable Nanograspers for Rapid Nanoplastics Detection in Biological Fluids

Area of Science:

• Analytical Chemistry
• Materials Science
• Environmental Science

Background:

• Effective detection of nanoplastics in complex biological and environmental samples is crucial for public health and environmental protection.
• Current methods for nanoplastic detection lack efficiency and reliability, necessitating innovative solutions.

Purpose of the Study:

• To develop a novel sensing platform for rapid and reliable detection of nanoplastics and other analytes.
• To enhance analyte enrichment and improve the reproducibility of Surface-Enhanced Raman Scattering (SERS) measurements.

Main Methods:

• Development of optoelectronic-tweezer-assisted nanograspers (OET-NGP) using light-programmable metallic nanoparticle assemblies.
• Utilizing OET-NGP for rapid analyte enrichment and formation of uniform SERS hotspots.
• Application of the OET-NGP platform for in situ capture and SERS detection of nanoplastics in aqueous media and serum.

Main Results:

• Achieved a low detection limit of 4.43 × 10^-8 M for Rhodamine B.
• Demonstrated improved Surface-Enhanced Raman Scattering (SERS) reproducibility through uniform hotspot formation.
• Successfully detected nanoplastics at μg/mL levels in both aqueous solutions and biological serum samples in situ.

Conclusions:

• The OET-NGP system is a powerful and versatile sensing tool for effective nanoplastic detection.
• This technology holds significant potential for advancing environmental monitoring and biosafety assessments.
• The reconfigurable nature of OET-NGP allows for dynamic adaptation to various analytical challenges.