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α-AMA induced liver failure is associated with elevation of HMGB1 lactylation modification in mice

Shaofang Huang1, Jian Tao1, Hui Xiao1

  • 1Department of Emergency, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 17, Yongwai Center Street, Nanchang, Jiangxi, 330006, China.

BMC Gastroenterology
|March 4, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
ApoptosisHMGB1LactylationLiver failureProliferationΑ-amanitin

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DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic shunting—including...

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