Electrochemical Oxy-Carbofunctionalization of Alkenes with Alcohols and 1,3-Dicarbonyl Compounds
Bingjie Jian1,2, Rongxing Linghu1,2, Jun Shi1,2
1State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550014, P. R. China.
Abstract:
We developed an electrochemical oxidative oxyalkylation of alkenes with alcohols and 1,3-dicarbonyl compounds to produce diverse 1,3-dicarbonyl modified benzyl ethers in yields of 34-81%. This operationally simple and green process uses an undivided cell with commercial carbon electrodes at room temperature. The alcohol acts as the oxygenation reagent and solvent, and only H2 was generated as a byproduct. The synthetic utility of this method was demonstrated in the rapid synthesis of highly functionalized pyrazole, isoxazole, and 1,4-ketoalcohols compounds through late-stage functional transformations.
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