Jove
Visualize
Contact Us

Related Concept Videos

Traumatic Brain Injury l: Introduction01:28

Traumatic Brain Injury l: Introduction

25
DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...
25

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Geneticization studies as a theoretical field: an uneven history and conceptual reconstruction.

History and philosophy of the life sciences·2026
Same author

Radiologic factors in thoracolumbar burst fractures with versus without neurologic deficit: a systematic review and meta-analysis.

Spinal cord·2026
Same author

Histopathological Effects of the Intrathecal Chondroitinase ABC Administration in Spinal Cord Injured Rats: A Systematic Review.

Basic and clinical neuroscience·2026
Same author

A robust stacked ensemble strategy with multi-optimizer CNN models for skin cancer classification.

Scientific reports·2026
Same author

Process optimization of laser metal deposition for fabrication of AlCoCrFeNi<sub>2.1</sub> high-entropy alloy.

Scientific reports·2026
Same author

Medicine-art interaction in the development of modern anatomy education in Iran: focusing on the Post-Dār al-Funūn Era.

Journal of medical ethics and history of medicine·2026
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 4, 2026

Microvascular Decompression: Salient Surgical Principles and Technical Nuances
10:35

Microvascular Decompression: Salient Surgical Principles and Technical Nuances

Published on: July 5, 2011

47.5K

To Do or Not to Do: Decompressive Craniectomy for Severe Traumatic Brain Injury.

Emad Hossein Raoufi1,2, Mahgol Sadat Hassan Zadeh Tabatabaei1, Hamidreza Namazi3

  • 1Sina Trauma and Surgery Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Asian Journal of Neurosurgery
|March 5, 2026
PubMed
Summary

Decompressive craniectomy (DC) for severe traumatic brain injury (TBI) reduces mortality but often results in poor outcomes. This review examines DC

Keywords:
CRASHIMPACTdecompressive craniectomyprognostic modelsresource allocationrole of rescuetraumatic brain injury

More Related Videos

Controlled Cortical Impact Model for Traumatic Brain Injury
05:30

Controlled Cortical Impact Model for Traumatic Brain Injury

Published on: August 5, 2014

29.8K
Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury
05:01

Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury

Published on: August 16, 2019

11.2K

Related Experiment Videos

Last Updated: May 4, 2026

Microvascular Decompression: Salient Surgical Principles and Technical Nuances
10:35

Microvascular Decompression: Salient Surgical Principles and Technical Nuances

Published on: July 5, 2011

47.5K
Controlled Cortical Impact Model for Traumatic Brain Injury
05:30

Controlled Cortical Impact Model for Traumatic Brain Injury

Published on: August 5, 2014

29.8K
Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury
05:01

Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury

Published on: August 16, 2019

11.2K

Area of Science:

  • Neurosurgery and Neurotrauma
  • Critical Care Medicine
  • Health Economics and Ethics

Background:

  • Severe traumatic brain injury (TBI) is a leading cause of death and disability, especially in young adults.
  • Elevated intracranial pressure (ICP) management is critical, with decompressive craniectomy (DC) a debated intervention.
  • DC aims to reduce ICP and improve cerebral perfusion but has variable functional outcomes.

Purpose of the Study:

  • To synthesize evidence on the clinical effectiveness, cost-utility, and ethical considerations of DC in severe TBI.
  • To explore the utility of prognostic models in decision-making for DC.
  • To provide a comprehensive understanding to support clinical and ethical decision-making in TBI management.

Main Methods:

  • Comprehensive literature review of clinical, ethical, and economic evidence on DC in severe TBI.
  • Inclusion of expert opinions to supplement evidence.
  • Analysis of prognostic models like CRASH and IMPACT for outcome prediction.

Main Results:

  • DC effectively reduces mortality but is associated with significant long-term disability and reduced quality of life.
  • Cost-effectiveness of DC varies by patient age and injury severity, being more favorable in younger patients.
  • Prognostic models offer evidence-based predictions but have limitations in accuracy and application under stress.

Conclusions:

  • The decision for DC in severe TBI involves complex trade-offs between mortality reduction and functional outcomes.
  • Ethical resource allocation and shared decision-making require careful consideration of prognostic uncertainty.
  • Further research and refined predictive tools are needed to optimize DC use and patient care in TBI.