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Colistin-Associated Acute Kidney Injury in Burn Patients: Incidence, Associated Factors and Prognosis
S Ben Massoud1,2, H Fredj1,3,2, A Mokline1,3,2
1Service de Réanimation des Brûlés, Centre de Traumatologie et des Grands Brûlés, Tunis, Tunisie.
None:
Colistin is often essential in burn patients presenting infections caused by multidrug-resistant organisms. A retrospective study was conducted in the intensive burn care department in Tunisia over 14 months to assess prevalence and predictive factors of colistin-related acute kidney injury (AKI). Among 70 patients (mean age 34±13 years), 28.6% developed AKI, with onset at 5±2 days. Associated factors included total burned surface area >41% (OR=2.6), UBS score >58 (OR=6.8), metabolic acidosis at admission (OR=28) and contrast agent injection (OR=107). AKI was reversible in 40% of cases. Colistin-associated AKI remains a frequent complication in severely burned patients, and in cases of contrast agent use.
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