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Hypersensitivity Reactions: Immune-Complex Reactions01:19

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Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
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Acute Encephalopathy From Central Nervous System Hemophagocytic Lymphohistiocytosis (CNS HLH) in X-Linked Lymphoproliferative Disease Type 1 (XLP-1).

Journal of child neurologyยท2026
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Updated: Mar 6, 2026

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
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An abnormal immune response masquerading as infectious conditions.

Quynh Kieu1,2, Brianna Leyden1

  • 1Department of Pediatrics, CHOC Hospital, Orange, CA, USA.

SAGE Open Medical Case Reports
|March 5, 2026
PubMed
Summary

Kikuchi-Fujimoto disease (KFD) is a rare lymphadenitis. This case highlights a young female with fever, lymphadenopathy, and elevated IL-18, diagnosed via biopsy and treated with corticosteroids.

Area of Science:

  • Pediatrics
  • Immunology
  • Pathology

Background:

  • Kikuchi-Fujimoto disease (KFD) is a rare, benign lymphadenitis of unknown etiology, often linked to immune dysregulation.
  • It primarily affects young adults and children, particularly females of Asian descent.
Keywords:
cytopenialymphadenopathylymphomaprolonged fever

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