Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

2.2K
Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
2.2K
Nucleosome Remodeling02:54

Nucleosome Remodeling

11.5K
Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure.
Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...
11.5K
Epigenetic Regulation01:37

Epigenetic Regulation

4.0K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
4.0K
Epigenetic Regulation01:46

Epigenetic Regulation

34.1K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
34.1K
Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

2.2K
Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
2.2K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

38.1K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
38.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of the homozygous truncating mutation in <i>CNTD1</i> as a novel genetic cause of diminished ovarian reserve.

Genes & diseases·2026
Same author

Early local antitoxin intervention attenuates botulinum neurotoxin-induced neuromuscular dysfunction.

Toxicon : official journal of the International Society on Toxinology·2026
Same author

Shared molecular signatures linking gastroesophageal reflux disease and major depressive disorder revealed by integrated machine learning.

BMC gastroenterology·2026
Same author

Pre-implantation embryo metabolism identified by PEMA reveals endogenous lactate insufficiency contributes to pre-implantation development arrest.

Fundamental research·2026
Same author

Segmental specification of the human female fetal reproductive tract revealed by spatiotemporal dynamics.

Nature cell biology·2026
Same author

Mocetinostat Ameliorates Pathological Cardiac Hypertrophy via Suppression of Ferroptosis Through Nrf2 Pathway.

Die Pharmazie·2026
Same journal

Advancing fat graft survival: from adipose-derived stem cell mechanisms to next-generation regenerative strategies.

Frontiers in cell and developmental biology·2026
Same journal

CRISPR-based next-generation molecular diagnostics for bone infection.

Frontiers in cell and developmental biology·2026
Same journal

Tissue turnover and rejuvenation through mechanics.

Frontiers in cell and developmental biology·2026
Same journal

Decoding signaling crosstalk in pulpitis: pathogenesis and precision therapeutics.

Frontiers in cell and developmental biology·2026
Same journal

Embryonic scaling: morphogen gradients, size sensing, and scaler genes.

Frontiers in cell and developmental biology·2026
Same journal

H<sub>2</sub>S-mediated protein S-sulfhydration: a novel regulatory module in lipid metabolism.

Frontiers in cell and developmental biology·2026
See all related articles

Related Experiment Video

Updated: Mar 6, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

10.9K

Epigenetic remodeling during early embryonic development.

Xiaoyu Wan1,2, Shibin Zhang3, Jingyu Li2

  • 1Department of Physiology, College of Basic Medical Science, Zunyi Medical University, Zunyi, Guizhou, China.

Frontiers in Cell and Developmental Biology
|March 5, 2026
PubMed
Summary
This summary is machine-generated.

Early embryonic development involves significant epigenetic reprogramming. This review details dynamic changes in DNA methylation, histone modifications, and chromatin architecture during mammalian embryogenesis.

Keywords:
early embryo developmentepigenetic reprogramminghistone modificationsmammalsmetabolically-associated histone marks

More Related Videos

Zygotic Fluorescence Recovery After Photo-bleaching Analysis for Chromatin Looseness That Allows Full-term Development
10:30

Zygotic Fluorescence Recovery After Photo-bleaching Analysis for Chromatin Looseness That Allows Full-term Development

Published on: June 12, 2018

8.4K
Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues
13:03

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues

Published on: June 3, 2016

8.7K

Related Experiment Videos

Last Updated: Mar 6, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

10.9K
Zygotic Fluorescence Recovery After Photo-bleaching Analysis for Chromatin Looseness That Allows Full-term Development
10:30

Zygotic Fluorescence Recovery After Photo-bleaching Analysis for Chromatin Looseness That Allows Full-term Development

Published on: June 12, 2018

8.4K
Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues
13:03

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues

Published on: June 3, 2016

8.7K

Area of Science:

  • Developmental Biology
  • Epigenetics
  • Genomics

Background:

  • Mammalian embryonic development involves a transition from totipotency to pluripotency.
  • This developmental progression is accompanied by extensive epigenetic reprogramming.
  • Understanding these epigenetic dynamics is crucial for developmental biology.

Purpose of the Study:

  • To synthesize recent advances in understanding epigenetic reprogramming during early embryogenesis in mice and humans.
  • To focus on the dynamic features of histone modifications and their role in development.
  • To highlight emerging metabolic-associated histone modifications.

Main Methods:

  • Review of recent scientific literature on epigenetic remodeling in early embryogenesis.
  • Analysis of low-input multi-omics technologies and other relevant methods.
  • Synthesis of data on DNA methylation, histone modifications, chromatin accessibility, and 3D chromatin architecture.

Main Results:

  • Detailed elaboration on common histone modifications (methylation, acetylation, ubiquitination) during embryogenesis.
  • Identification of dynamic patterns in histone variant incorporation.
  • Outline of emerging roles for metabolism-associated modifications like crotonylation and lactylation.

Conclusions:

  • Epigenetic reprogramming, particularly histone modification dynamics, is central to mammalian early development.
  • Novel metabolic-associated modifications play significant roles in genomic targeting and transcriptional regulation.
  • Continued research using advanced multi-omics technologies will further elucidate these complex processes.