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Transfer RNA-derived small RNAs (tsRNAs) in Alzheimer's disease: emerging mechanisms and diagnostic potential
Juan Zhang1, Jialuo Han2, Qiang Liu2,3,4
1Department of Pathophysiology, School of Basic Medical Sciences, Wannan Medical College, Wuhu, Anhui, China.
Abstract:
Transfer RNA-derived small RNAs (tsRNAs), a class of non-coding RNAs derived from precursor or mature tRNAs, are now recognized as critical regulators in response to cellular stress. tsRNAs exhibit differential expression during brain aging and in age-related neurodegenerative disorders such as Alzheimer's disease (AD), suggesting their involvement in the molecular processes underlying neuronal aging and degeneration. This article summarizes recent advances in our understanding of tsRNA biogenesis, classification, and function, emphasizing their regulatory role in brain aging and AD pathology. We also highlight the diagnostic and therapeutic implications of tsRNAs and discuss future directions for exploring their mechanistic and clinical relevance.
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