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Psychomotor and neurofunctional sequelae after COVID-19
Lara L W Chiminazzo1, Ivana B Suffredini1, Thiago B Kirsten1
1Psychoneuroimmunology Laboratory, Program in Environmental and Experimental Pathology, Paulista Universityhttps://ror.org/020v13m88, Brazil.
Acta Neuropsychiatrica
|March 5, 2026
Summary
Long COVID causes lasting psychomotor and neurofunctional impairments, particularly affecting memory in younger adults and motor skills in middle-aged individuals. Rh-negative blood type may increase risk.
Area of Science:
- Neurology
- Infectious Diseases
- Public Health
Background:
- Previous research identified psychomotor and neurofunctional deficits post-SARS-CoV-2 infection.
- Long COVID (post-COVID-19 syndrome) requires further characterization regarding persistent symptoms.
Purpose of the Study:
- To assess the persistence of psychomotor and neurofunctional impairments 24 weeks after SARS-CoV-2 infection.
- To explore correlations between these sequelae and factors like age, blood type, symptoms, and medical care.
Main Methods:
- 30 post-COVID-19 participants and 30 controls underwent psychomotor and cognitive tests at baseline, 12, and 24 weeks.
- Tests included fine motor skills, balance, episodic memory, verbal fluency, and clock drawing.
- Participants were stratified by age, symptoms, medical care, and blood type.
Main Results:
- Psychomotor and neurofunctional deficits persisted for at least 24 weeks post-infection.
- Impairments were more pronounced in the 31-45 age group, while memory issues were more common in the 18-30 group.
- Body pain, coryza, sore throat, and Rh-negative blood type were associated with persistent sequelae.
Conclusions:
- Long COVID encompasses sustained psychomotor and neurofunctional deficits.
- These sequelae show associations with specific clinical (symptoms) and biological (blood type) variables.
- Findings suggest premature aging and highlight the need for comprehensive long COVID management.
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