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Related Experiment Video

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Hypoxia Alters miRNAs Levels Involved in Non-Mendelian Inheritance of Autism Spectrum Disorder in Mice
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Study on miRNA-146a-5p rs2910164 polymorphism in attention deficit and hyperactive disorder occurrence and

Wenmin Zhuang1, Xuemin Ding2, Haixia Luo2

  • 1School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China.

Personalized Medicine
|March 5, 2026
PubMed
Summary

The miR-146a-5p rs2910164 polymorphism is linked to attention deficit hyperactivity disorder (ADHD) susceptibility in Chinese children. Specific genotypes influence ADHD risk and response to methylphenidate (MPH) treatment.

Keywords:
attention deficitdevelopmenthyperactive disordermiR-146a-5prs2910164 polymorphism

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Area of Science:

  • Genetics
  • Neuroscience
  • Molecular Biology

Background:

  • Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder.
  • MicroRNAs (miRNAs) play crucial roles in gene regulation and have been implicated in various neurological conditions.
  • The miR-146a-5p rs2910164 polymorphism is a potential genetic factor influencing disease susceptibility.

Purpose of the Study:

  • To investigate the association between the miR-146a-5p rs2910164 polymorphism and ADHD in a Chinese pediatric population.
  • To explore the relationship between this polymorphism, miR-146a-5p expression levels, and treatment response to methylphenidate (MPH).

Main Methods:

  • A case-control study involving 180 children diagnosed with ADHD and 122 healthy controls (aged 6-12 years).
  • Genotyping of the miR-146a-5p rs2910164 polymorphism using the TaqMan Genotyping method.
  • Quantification of miR-146a-5p levels via qRT-PCR and statistical analysis using multivariate logistic regression.

Main Results:

  • ADHD children with the GG genotype had significantly higher miR-146a-5p levels compared to GC/CC carriers.
  • The G allele and male subgroup were associated with increased ADHD susceptibility.
  • Individuals with GC/CC genotypes showed better treatment response to MPH compared to GG individuals.

Conclusions:

  • The miR-146a-5p rs2910164 polymorphism is associated with ADHD in the Chinese population.
  • This polymorphism may influence ADHD susceptibility and MPH treatment outcomes.
  • Further validation in larger, independent cohorts is warranted to confirm generalizability.