Related Experiment Video
Updated: Mar 6, 2026

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
Published on: July 16, 2014
Concerns About Gabapentinoids in Psychiatric Practice
1Georgetown University Berkley School of Nursing, Washington, D.C.
Abstract:
Similar to benzodiazepines, gabapentinoids are used to reduce central nervous system hyperexcitability. Unlike benzodiazepines, gabapentinoids are not approved by the U.S. Food and Drug Administration for the treatment of psychiatric disorders, even in disorders characterized by excitatory-inhibitory imbalances in neuronal circuits. The current article explores the indications, concerns, trends in prescribing, and clinical guidance offered to clinicians for making safe decisions regarding use of gabapentinoids.
More Related Videos
Related Concept Videos
Antiepileptic Drugs: GABAergic Pathway Potentiators
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
Antiepileptic Drugs: Glutamate Antagonists
Sedatives and Hypnotics Drugs: Miscellaneous Agents
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Antiepileptic Drugs: Potassium Channel Activators
Ezogabine has gained approval as an adjunctive treatment...
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
Antidepressant Drugs: MAOIs and Other Agents

