Mapping Long-Term Memory Modulation With Transcranial Alternating Current Stimulation
Dima Chitic1, Miles Wischnewski1
1Department of Psychology, University of Groningen, Groningen, The Netherlands; Research School of Behavioral and Cognitive Neurosciences, University of Groningen, Groningen, The Netherlands.
Background:
Long-term memory (LTM), which is the ability to retain information for a long period, is governed by neural oscillations in various parts of the cerebral cortex. To investigate the relationship between oscillations and memory performance, transcranial alternating current stimulation (tACS) has been used to modulate LTM. However, owing to the variability in stimulation parameters and locations, no clear picture has emerged on where tACS needs to be applied to improve LTM.
Materials And Methods:
We collected behavioral data from 20 studies (58 effect sizes) and computationally modeled the corresponding brain electric fields on the basis of each study's unique tACS parameters. As a result, we generated a map of performance-electric field index values using linear and quadratic fits.
Results:
Theta-tACS showed no regions with a positive linear association with LTM. However, left lateral prefrontal and temporal areas exhibited negative associations, meaning that theta stimulation of that region led to decreased LTM performance. A quadratic analysis revealed a U-shaped relation in the medial temporal and ventromedial prefrontal cortex, suggesting improved memory at low and high, but not moderate, electric field strength values. Gamma-tACS showed positive linear associations in parieto-occipital cortex and negative ones in frontal regions. For gamma, we found no regions that expressed a quadratic relationship.
Conclusion:
These findings indicate that LTM-relevant tACS effects are frequency- and site-specific, and potentially nonlinear with respect to intensity. Integrating meta-analytic effect sizes with individualized field estimates provides a brain-wide framework for identifying targets of memory modulation and for guiding future fundamental and translational research.
