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The Association Between Self-reported Shift Work and Change in Kidney Function in Women and Men in a Multiethnic
Taryn G Vosters1, Dide J van de Fliert1, Kitty J Jager2
1From the Department of Public and Occupational Health, Amsterdam UMC, Location VUmc, University of Amsterdam, Amsterdam Public Health Institute, Amsterdam, The Netherlands (T.G.V., D.J.F., K.N., G.W.M.W., B.-J.B., H.G., I.G.M.V.).
Objective:
This study investigated the association between self-reported shift work and change in kidney function in women and men in a multiethnic cohort.
Method:
Data from the prospective Life in Urban Setting (HELIUS) cohort (3812 women, 3488 men), including adults from 6 ethnic backgrounds based in the Netherlands, were used to assess associations between self-reported shift work and change in estimated glomerular filtration rate (eGFR) and albumin to creatinine ratio (ACR) using sex-stratified linear regressions and mediation analyses.
Results:
Shift work was associated with a significant decline in eGFR but not ACR among men versus non-shift workers. No significant associations were found for change in eGFR or ACR in women overall. No evidence was found for a mediating role of traditional- and lifestyle-related chronic kidney disease risk factors.
Conclusion:
Shift work may be detrimental to kidney health. Employers and policymakers should consider addressing the potential kidney health risks of shift work, particularly in men.
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