Accuracy of Intraocular Lens Power Calculation Formulas in Cataract Eyes after Vitrectomy with Silicone Oil
Peng Zhao1,2, Meng Li2, Zhao-Xing Guo2
1School of Clinical Medicine, Shandong Second Medical University, Weifang, China.
Ophthalmic Research
|March 5, 2026
Summary
Newer artificial intelligence formulas, particularly Kane and EVO, offer superior accuracy for intraocular lens calculations in eyes with silicone oil after vitrectomy compared to traditional methods.
Area of Science:
- Ophthalmology
- Artificial Intelligence
- Biomedical Engineering
Background:
- Cataract surgery requires precise intraocular lens (IOL) power calculation.
- Vitrectomy with silicone oil tamponade presents unique challenges for IOL calculation accuracy.
- Traditional formulas may not perform optimally in these complex cases.
Purpose of the Study:
- To systematically compare the accuracy of artificial intelligence (AI) and traditional IOL calculation formulas.
- To evaluate formula performance in eyes that have undergone vitrectomy with silicone oil tamponade.
- To identify the most accurate formulas for this specific patient population.
Main Methods:
- A meta-analysis of studies published up to October 29, 2025, from major databases (PubMed, Cochrane, Embase, Web of Science).
- Inclusion of 12 IOL calculation formulas: SRK/T, Hoffer Q, Hoffer QST, Haigis, Barrett Universal II, Holladay I, Holladay II, RBF, LSF, EVO, Kane, and Pearl-DGS.
- Primary outcomes measured were the percentage of eyes with prediction errors (PE) within ±0.50D and ±1.00D.
Main Results:
- The meta-analysis included 7 studies with 1060 eyes.
- Newer AI-driven formulas demonstrated higher accuracy than traditional formulas.
- The Kane formula showed the highest precision for prediction errors within ±0.50D.
- The EVO formula performed best for prediction errors within ±1.00D, with Kane also ranking highly.
- The RBF formula also demonstrated strong performance.
Conclusions:
- The Kane and EVO formulas are recommended as superior choices for IOL power calculation in eyes filled with silicone oil after vitrectomy.
- These advanced formulas offer improved accuracy over traditional methods in complex post-vitrectomy eyes.
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