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Association of Glymphatic Dysfunction with Cognitive Performance in Type 2 Diabetes Mellitus and Prediabetes

Liya Gong1, Jing He1, Ziqi Wu1

  • 1Department of Medical Imaging, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Neuroendocrinology
|March 5, 2026
PubMed
Summary

Prediabetes and type 2 diabetes show glymphatic system (GS) changes, including altered diffusion tensor imaging-anisotropic diffusion along the perivascular space (DTI-ALPS) index and cerebrospinal fluid (CSF) space, linked to cognitive decline.

Keywords:
Cognitive functionGlymphatic systemMagnetic resonance imagingPrediabetesType 2 diabetes mellitus

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