Gene-Genie! A web-based artificial intelligence platform supporting site preparedness for gene therapy.

Area of Science:

• Biotechnology
• Artificial Intelligence
• Pharmacology

Background:

• Recombinant Adeno-Associated Virus (rAAV) gene therapies are approved for rare diseases, necessitating specialized expertise for clinical use.
• The complexity of gene therapy implementation poses challenges for healthcare professionals.

Purpose of the Study:

• To develop and evaluate 'Gene-Genie,' an AI chatbot designed for expert guidance on rAAV gene therapy implementation.
• To assess the chatbot's accuracy, reliability, and utility for hospital pharmacy leaders.

Main Methods:

• Phase 1: Development and technical testing of the AI chatbot by a multidisciplinary team.
• Phase 2: Exploratory pilot study evaluating the chatbot's impact on perceived knowledge using pre- and post-intervention questionnaires with pharmacy leaders.

Main Results:

• The AI chatbot, Gene-Genie, was successfully developed, providing accurate and context-aware information.
• Post-use, participants showed improved perceived knowledge (mean score increase from 17.0 to 20.0).
• A majority of participants (62.5%) would recommend Gene-Genie to peers for gene therapy implementation support.

Conclusions:

• Gene-Genie, a domain-specific AI chatbot for gene therapy, has been successfully developed.
• Exploratory results indicate its potential value for hospital pharmacy leadership in facilitating gene therapy program implementation.