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Heterogeneous Catalysis

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Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs

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Asymmetric Homogeneous Oxidation Reactions Catalyzed by First-Row Transition Metal Complexes.

Geeta Devi Yadav^1,2, Deepa Uppal¹, Priyanka Jhajharia³

¹Department of Chemistry, University of Delhi, New Delhi, India.

|March 5, 2026

Summary

This summary is machine-generated.

This review summarizes asymmetric homogeneous oxidation reactions using first-row transition metal complexes. It highlights chiral catalyst performance, focusing on ligands, metals, and reaction conditions for efficient oxidation catalysis.

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Area of Science:

Catalysis
Organic Chemistry
Materials Science

Background:

Asymmetric homogeneous oxidation reactions are crucial for synthesizing chiral molecules.
First-row transition metal complexes offer cost-effective and sustainable catalytic solutions.
Understanding catalyst performance requires analyzing key factors like ligand structure and reaction conditions.

Purpose of the Study:

To review asymmetric homogeneous oxidation reactions catalyzed by first-row transition metal complexes.
To analyze the relationship between chiral catalyst performance and key factors.
To provide a comprehensive overview of homogeneous asymmetric oxidation catalysts.

Main Methods:

Literature review of asymmetric homogeneous oxidation reactions.
Focus on catalytic systems involving first-row transition metals and chiral ligands.
Analysis of various oxidants including hydrogen peroxide, molecular oxygen, and tert-butyl hydroperoxide.

Main Results:

Manganese complexes are extensively used for epoxidation, hydroxylation, and oxidative kinetic resolution.
Various first-row transition metals (Ti, Cr, Mn, Fe, Co, V) and chiral ligands are employed.
Diverse oxidation reactions are achieved, including epoxidation, sulfoxidation, and hydroxylation.

Conclusions:

First-row transition metal complexes are effective homogeneous catalysts for asymmetric oxidation.
Chiral ligand design and reaction parameters significantly influence catalyst performance.
This review enhances the understanding of homogeneous asymmetric oxidation catalysis.