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Related Experiment Video

Updated: Jun 15, 2026

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
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Spatial navigation as a digital marker for clinically differentiating cognitive impairment severity.

Giorgio Colombo1,2, Karolina Minta3,4, William R Taylor3,5

  • 1Future Health Technologies, Singapore-ETH Centre, Campus for Research Excellence And Technological Enterprise (CREATE), Singapore, Singapore. gicolombo@ethz.ch.

Communications Medicine
|March 5, 2026
PubMed
Summary
This summary is machine-generated.

The Spatial Performance Assessment for Cognitive Evaluation (SPACE) digital tool accurately detects cognitive impairment by assessing spatial navigation deficits. A brief version maintains high diagnostic accuracy, aiding early Alzheimer's disease detection.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Digital Health

Background:

  • Spatial navigation deficits are early indicators of Alzheimer's disease.
  • Current assessments are often impractical for routine cognitive screening.
  • The Spatial Performance Assessment for Cognitive Evaluation (SPACE) is a novel digital tool for evaluating these deficits.

Purpose of the Study:

  • To evaluate the efficacy of the SPACE tool in assessing spatial navigation ability.
  • To compare SPACE performance against clinical diagnoses and standard cognitive tests.
  • To determine SPACE's utility in detecting cognitive impairment in older adults.

Main Methods:

  • 300 older adults were assessed using SPACE, categorized by Clinical Dementia Rating (CDR) scale.
  • SPACE performance was analyzed using Area Under the ROC Curve (AUC), sensitivity, and specificity.
  • Comparisons were made with clinical diagnosis, neuropsychological tests, and demographic models.

Main Results:

  • SPACE reliably distinguished between different CDR levels, outperforming demographic models.
  • SPACE significantly improved AUC for differentiating dementia stages (e.g., no dementia vs. mild dementia: 0.76 to 0.94).
  • A shortened SPACE version (under 11 minutes) maintained high diagnostic accuracy, reducing administration time by 40%.

Conclusions:

  • Digital spatial navigation assessments like SPACE show promise for early Alzheimer's disease detection.
  • SPACE offers a scalable and accessible method for cognitive screening.
  • These findings support the integration of digital tools in dementia care pathways.