Related Experiment Video

Updated: Jun 28, 2026

Assays for Validating Histone Acetyltransferase Inhibitors
09:11

Assays for Validating Histone Acetyltransferase Inhibitors

Published on: August 6, 2020

7.1K

A small‑molecule HDAC/PDE modulator activates human adipocyte UCP1 and resolves inflammatory signaling

Mayyasa Rammah1,2, Atilio Reyes Romero1,2,3, Najeeb Halabi1,2

  • 1Genetic Intelligence Laboratory, Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, P.O. Box 24144, Doha, Qatar.

Journal of Translational Medicine
|March 5, 2026
PubMed
Summary

No abstract available in PubMed .

Keywords:
Adipocyte browningHDACInflammationObesityPDEThermogenesisUCP1

More Related Videos

Investigation of Beige Fat Biology and Metabolism Using the CRISPR SunTag-p65-HSF1 Activation System
09:52

Investigation of Beige Fat Biology and Metabolism Using the CRISPR SunTag-p65-HSF1 Activation System

Published on: January 6, 2023

2.9K
Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator
06:08

Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator

Published on: May 19, 2023

3.0K

Related Experiment Videos

Last Updated: Jun 28, 2026

Assays for Validating Histone Acetyltransferase Inhibitors
09:11

Assays for Validating Histone Acetyltransferase Inhibitors

Published on: August 6, 2020

7.1K
Investigation of Beige Fat Biology and Metabolism Using the CRISPR SunTag-p65-HSF1 Activation System
09:52

Investigation of Beige Fat Biology and Metabolism Using the CRISPR SunTag-p65-HSF1 Activation System

Published on: January 6, 2023

2.9K
Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator
06:08

Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator

Published on: May 19, 2023

3.0K

Related Concept Videos

GPCRs Regulate Adenylyl Cylase Activity01:09

GPCRs Regulate Adenylyl Cylase Activity

Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of cells.
Two...
cAMP-dependent Protein Kinase Pathways01:25

cAMP-dependent Protein Kinase Pathways

Cyclic Adenosine Monophosphate (cAMP) is an essential second messenger that activates protein kinase A (PKA) and regulates various biological processes. A single epinephrine molecule binds to GPCR and activates several heterotrimeric G proteins, each stimulating multiple adenylyl cyclase, amplifying the signal, and synthesizing large numbers of cAMP molecules. Small changes in cAMP concentration affect PKA activity. The binding of four cAMP molecules induces a conformational change in PKA,...

Articles linked to this work by shared authors, journal, and citation graph.

Geometry-dependent interfaces shape NLRP3 pyrin domain assembly.

International journal of biological macromolecules·2026

An Ugi-Joullié Platform for Medicinally Relevant 1,4-Dihydrobenzothiazines.

ChemMedChem·2026

One Face, Three Solutions: Structural Convergence in PD-L1 Inhibition across Antibodies, Macrocycles, and Small Molecules.

Journal of medicinal chemistry·2026

Baxdrostat: A First-in-Class Aldosterone Synthase Inhibitor for Resistant Hypertension.

ACS pharmacology & translational science·2026

Ugi-Tetrazole-Derived α‑Aminomethyl Scaffolds Reveal Unexpected Binding Modes in SARS-CoV‑2 3CLpro.

ACS medicinal chemistry letters·2026

Systematic Expansion of an Ugi-Based Multicomponent Synthesis of Tetrasubstituted Imidazoles.

ACS omega·2026

Efficacy and safety of AAV RPGR gene therapy in X-linked retinitis pigmentosa: a systematic review and meta-analysis.

Journal of translational medicine·2026

IL-17 Receptor inhibition with brodalumab limits experimental periodontitis.

Journal of translational medicine·2026

Targeting the IL-17C-M2 macrophage axis ameliorates fibrosis in endometriosis through MAPK/ERK signaling.

Journal of translational medicine·2026

Supplementation of αKG along with TGFβ/HIF1α antagonist rescues lung fibrosis in mice with severe SARS-CoV-2 infection.

Journal of translational medicine·2026

Interaction between p-AMPK and RIPK3 reveals a mechanism by which AdipoAI suppresses necroptosis to attenuate periodontitis.

Journal of translational medicine·2026

Impaired NADH-linked mitochondrial respiration disrupts ventral midbrain neuronal programs in POLG disease.

Journal of translational medicine·2026

Systematic Scanning Mutagenesis Unveils the Structure-Function Landscape Enabling Aptamer Evolution.

Analytical chemistry·2026

Energy-Decoupled Photoelectrochemical and Pressure Dual-Mode Biosensors for Machine-Learning-Assisted Immunoassay.

Analytical chemistry·2026

Cardiac microphysiological systems in cardiovascular research: Construction paradigms, maturation trajectories, and translational frontiers.

Bioengineering & translational medicine·2026

Dopamine triggers TOR signaling cascade to drive biomass and astaxanthin hyperaccumulation in Haematococcus lacustris under coordinated salinity and gradient light stress.

Bioresource technology·2026

Computational models show that functional remodeling, not anatomy, reshapes physiological determinants of cardiac performance in hypertrophic cardiomyopathy.

Journal of molecular and cellular cardiology·2026

Improving surgical planning for patients with deep endometriosis using patient specific 3D anatomical models: A randomized prospective trial.

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us