Related Experiment Video
Updated: Mar 7, 2026
Creation of Abdominal Adhesions in Mice
Published on: August 27, 2016
Histopathological features and tissue remodeling in chronic abdominal wall mesh infection - a clinicopathological
Daniel Ioan Mihalache1, Laurenţiu Augustus Barbu, Tiberiu Ştefăniţă Ţenea-Cojan
1Department of Surgery, University of Medicine and Pharmacy of Craiova, Romania; laurentiu.barbu@umfcv.ro; vliviu777@yahoo.com.
Background:
Chronic mesh infection is a severe implant-associated complication characterized by persistent inflammation and progressive tissue remodeling. This condition is closely associated with foreign body reaction (FBR), fibrosis, and biofilm-related chronic inflammatory processes, which significantly alter the structural integrity of the abdominal wall.
Patients, Materials And Methods:
We performed a retrospective clinicopathological study of patients treated for chronic abdominal wall mesh infection between January 2021 and December 2024. Explanted mesh specimens together with adjacent periprosthetic tissues were collected and processed using standard histological techniques, including formalin fixation, paraffin embedding, and Hematoxylin-Eosin staining. Histopathological (HP) evaluation focused on inflammatory infiltrates, FBR, fibrotic response, and tissue remodeling.
Results:
HP examination consistently demonstrated foreign body granulomatous reaction characterized by multinucleated giant cells surrounding mesh filaments, associated with chronic inflammatory infiltrates composed predominantly of lymphocytes and plasma cells. Extensive fibrosis and dense collagen deposition with fibrotic encapsulation of the prosthetic material were observed in all cases. These findings were associated with marked structural remodeling of the surrounding soft tissues.
Conclusions:
Chronic mesh infection is associated with characteristic HP features, including foreign body granulomatous reaction, chronic inflammation, and extensive fibrosis. These morphological alterations reflect persistent implant-associated inflammatory processes and contribute to progressive tissue remodeling. HP evaluation provides essential insights into the biological mechanisms underlying chronic mesh infection and its long-term tissue effects.
Related Concept Videos
01:24Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
01:17Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
01:30Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...