Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rh Blood Group01:19

Rh Blood Group

3.9K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Serial versus Once-Only Cervical Length Screening in Twin Pregnancies.

American journal of perinatology·2026
Same author

Factors associated with appropriate administration of magnesium sulfate for neuroprotection prior to early preterm birth.

American journal of obstetrics & gynecology MFM·2026
Same author

Navigating Drug Shortages in Obstetric Care.

O&G open·2026
Same author

The need for pharmacotherapy among patients with one or more elevations on glucose tolerance test.

The Journal of clinical endocrinology and metabolism·2026
Same author

Perceptual distortions during simultaneous continuous monitoring of fetal and maternal heart rate in laboring patients.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·2026
Same author

Maternal and neonatal outcomes in singleton pregnancies conceived using donor oocytes: a retrospective cohort study.

Maternal health, neonatology and perinatology·2025

Related Experiment Video

Updated: Mar 7, 2026

A Rapid, Simple, and Standardized Homogenization Method to Prepare Antigen/Adjuvant Emulsions for Inducing Experimental Autoimmune Encephalomyelitis
05:44

A Rapid, Simple, and Standardized Homogenization Method to Prepare Antigen/Adjuvant Emulsions for Inducing Experimental Autoimmune Encephalomyelitis

Published on: December 9, 2022

4.7K

Algorithm for RhD immune globulin shortage yields over 50 % dosage savings.

Gillian Piltch1,2,3,4, Frank Jackson1,4,5, Sarika Arora4

  • 1Northwell, New Hyde Park, NY, USA.

Journal of Perinatal Medicine
|March 6, 2026
PubMed
Summary

An evidence-based algorithm can significantly reduce RhD immune globulin (RhIG) usage in RhD-negative pregnant and postpartum individuals. This approach offers substantial RhIG dosage savings, crucial during shortages, while maintaining patient safety.

Keywords:
RhD immune globulinRhD-negativeRhIGshortagetriage

More Related Videos

An Optimized Hemagglutination Inhibition HI Assay to Quantify Influenza-specific Antibody Titers
06:34

An Optimized Hemagglutination Inhibition HI Assay to Quantify Influenza-specific Antibody Titers

Published on: December 1, 2017

38.2K
Quantification of Cellular Densities and Antigenic Properties using Magnetic Levitation
05:25

Quantification of Cellular Densities and Antigenic Properties using Magnetic Levitation

Published on: May 17, 2021

3.1K

Related Experiment Videos

Last Updated: Mar 7, 2026

A Rapid, Simple, and Standardized Homogenization Method to Prepare Antigen/Adjuvant Emulsions for Inducing Experimental Autoimmune Encephalomyelitis
05:44

A Rapid, Simple, and Standardized Homogenization Method to Prepare Antigen/Adjuvant Emulsions for Inducing Experimental Autoimmune Encephalomyelitis

Published on: December 9, 2022

4.7K
An Optimized Hemagglutination Inhibition HI Assay to Quantify Influenza-specific Antibody Titers
06:34

An Optimized Hemagglutination Inhibition HI Assay to Quantify Influenza-specific Antibody Titers

Published on: December 1, 2017

38.2K
Quantification of Cellular Densities and Antigenic Properties using Magnetic Levitation
05:25

Quantification of Cellular Densities and Antigenic Properties using Magnetic Levitation

Published on: May 17, 2021

3.1K

Area of Science:

  • Obstetrics and Gynecology
  • Immunology
  • Healthcare Management

Background:

  • RhD immune globulin (RhIG) prophylaxis is critical for RhD-negative individuals to prevent hemolytic disease of the fetus and newborn.
  • Periods of RhIG shortage necessitate evidence-based strategies to optimize its administration and conserve supply.
  • Existing RhIG administration guidelines may not fully account for resource limitations or emerging diagnostic technologies.

Purpose of the Study:

  • To develop and evaluate an evidence-based algorithm for RhIG administration in RhD-negative pregnant and postpartum individuals.
  • To quantify the potential RhIG dosage savings achievable through the implementation of this algorithm.
  • To assess the algorithm's impact on RhIG reserves during periods of shortage.

Main Methods:

  • A quality improvement study was conducted within a large metropolitan health system.
  • All RhIG dosages administered in inpatient and outpatient settings during 2023 were analyzed.
  • The developed algorithm was applied retrospectively to 2023 RhIG administration data to calculate potential dosage savings.

Main Results:

  • Implementation of the algorithm is estimated to yield over 50% RhIG dosage savings.
  • Specific scenarios showed significant savings: up to 85% in the first trimester by omitting RhIG for early abortions, 39% in the second and third trimesters by incorporating non-invasive prenatal screening for fetal RhD status, and 50% for postpartum individuals with a 150 µg (750 IU) dose.
  • The algorithm effectively targets RhIG administration, reducing unnecessary usage.

Conclusions:

  • The developed algorithm provides a practical framework for optimizing RhIG use in healthcare systems.
  • It enables maintenance of RhIG reserves during shortages without compromising patient safety.
  • This strategy supports efficient resource allocation in obstetric care.