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Investigating the Causal Links between the Aging Process and Alzheimer's Disease Pathogenesis
Jaewoo Seok1, Hyein Lee1, Jinsoo Seo1
1Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea.
International Journal of Stem Cells
|March 6, 2026
Summary
Aging societies face rising neurodegenerative diseases. This review questions classical cellular senescence markers for brain aging and proposes cell-type-specific markers for better biological age assessment.
Area of Science:
- Neuroscience
- Gerontology
- Cell Biology
Background:
- Global populations are aging, increasing neurodegenerative disease prevalence.
- Aging research increasingly focuses on biological age over chronological age.
- Cellular senescence is a key area of investigation for aging biomarkers.
Purpose of the Study:
- To review the limitations of current cellular senescence markers in the brain.
- To propose a new direction for identifying brain-specific aging markers.
Main Methods:
- Literature review of aging research and senescence markers.
- Analysis of the applicability of classical senescence markers to post-mitotic brain cells.
- Conceptual framework for cell-type-specific aging marker identification.
Main Results:
- Classical senescence markers have unclear validity in post-mitotic neurons.
- Current metrics may not accurately reflect biological aging in the brain.
- There is a need for brain-specific aging biomarkers.
Conclusions:
- Rethinking senescence markers is crucial for understanding brain aging.
- Developing cell-type-specific markers is essential for accurate biological age assessment in the brain.
- This approach will advance research into neurodegenerative disorders.
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