Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sweet and Bright: Illuminating Glycoprotein-Mediated Endocytosis via Metabolic Labeling and NanoLuciferase.

ACS chemical biology·2026
Same author

From biopolymers to Pickering emulsions: a green chemistry strategy to replace microplastics in next-generation cosmetics.

RSC advances·2026
Same author

Structural and Compositional Effects on the Scintillation Properties of Fast Emitting Metal-Organic Frameworks.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Transfer Printing of Epitaxial Organic Semiconductor Films.

ACS applied materials & interfaces·2026
Same author

Ultrafast scintillating metal-organic framework films.

Nature communications·2026
Same author

Phytochemical Profiling, Antioxidant Activity, and In Vitro Cytotoxic Potential of Mangrove <i>Avicennia marina</i>.

Pharmaceuticals (Basel, Switzerland)·2025
Same journal

Removal of Codispersible Residual Impurities from CuInS<sub>2</sub>/ZnS Quantum Dots for Window-Replaceable Luminescent Solar Concentrators.

ACS applied materials & interfaces·2026
Same journal

Durable Core-Shell Scatterer Coating with Heat Storage for Radiative Cooling.

ACS applied materials & interfaces·2026
Same journal

Calix[6]arene-Based Interlocked Inverse Vulcanizate Enabling Network-Interface Cooperative Reinforcement in Natural Rubber/Carbon Black Composites.

ACS applied materials & interfaces·2026
Same journal

Resolving Thermal Accumulation and Rigid-Soft Interface Mismatch in Stretchable Electronics with Cubic Boron Nitride Composite Islands.

ACS applied materials & interfaces·2026
Same journal

Enhancing Conversion Reversibility and Initial Coulombic Efficiency of SnO<sub>2</sub> Anodes via NiO/Ni-Carbon Interfacial Design.

ACS applied materials & interfaces·2026
Same journal

Multidimensional Interface Structure Design for High-Efficiency Optically Controlled Semiconductor Devices: A Case Study on Memristive Synapses.

ACS applied materials & interfaces·2026
See all related articles

Related Experiment Video

Updated: Mar 7, 2026

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
09:01

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

3.6K

Engineered Energy-Harvesting Hybrid Nanoscintillators for Enhanced Cancer Radiotherapy.

Valeria Secchi1,2, Irene Villa1,2, Samuela Sala1

  • 1Department of Materials Science, Milano-Bicocca University, Via R. Cozzi 55, Milano 20125, Italy.

ACS Applied Materials & Interfaces
|March 6, 2026
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel nanomaterial to improve radiotherapy. This material enhances reactive oxygen species (ROS) generation, significantly boosting cancer cell killing efficiency and safety for future cancer treatments.

Keywords:
energy harvestingnanomaterialsradiosensitization singlet oxygenradiotherapyscintillators

More Related Videos

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods
09:23

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods

Published on: October 10, 2025

1.6K
Plasmonic Photothermal Cancer Therapy: Nanoparticle-embedded Tumor-tissue-mimicking Phantoms for Visualizing Photothermal Temperature Distribution
06:42

Plasmonic Photothermal Cancer Therapy: Nanoparticle-embedded Tumor-tissue-mimicking Phantoms for Visualizing Photothermal Temperature Distribution

Published on: May 9, 2025

1.2K

Related Experiment Videos

Last Updated: Mar 7, 2026

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
09:01

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

3.6K
Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods
09:23

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods

Published on: October 10, 2025

1.6K
Plasmonic Photothermal Cancer Therapy: Nanoparticle-embedded Tumor-tissue-mimicking Phantoms for Visualizing Photothermal Temperature Distribution
06:42

Plasmonic Photothermal Cancer Therapy: Nanoparticle-embedded Tumor-tissue-mimicking Phantoms for Visualizing Photothermal Temperature Distribution

Published on: May 9, 2025

1.2K

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Radiation Oncology

Background:

  • Ionizing radiation in cancer therapy generates reactive oxygen species (ROS) via water radiolysis, causing DNA damage.
  • Current radiotherapy can be limited by the localized and efficient production of ROS.
  • Developing coadjutant agents is crucial to enhance radiotherapy efficacy and safety.

Purpose of the Study:

  • To design and develop a multicomponent nanomaterial as a prototype for radiotherapy coadjutant agents.
  • To enhance and localize ROS production by optimizing interaction with ionizing radiation and energy harvesting.
  • To improve the efficacy and safety of radiotherapy treatments.

Main Methods:

  • A multicomponent nanomaterial was synthesized with a magnesium silicate nanotube core and a dual layer of conjugated photosensitizers.
  • The nanomaterial's core was designed to enhance interaction with ionizing radiation.
  • The photosensitizer layers were engineered for singlet oxygen and ROS generation.

Main Results:

  • Exposure to X-rays resulted in a nearly 100-fold increase in singlet oxygen generation yield compared to previous systems.
  • The optimized nanomaterial architecture significantly boosted the harvesting of energy deposited by ionizing radiation.
  • Excellent glioblastoma cell-killing efficiency was observed at low concentrations of the nanomaterial.

Conclusions:

  • The developed multicomponent nanomaterial architecture is a promising model for next-generation radiotherapy coadjutants.
  • This approach significantly enhances ROS production, improving radiotherapy's efficacy and safety.
  • The findings support the potential of this nanomaterial for advanced cancer treatment strategies.