Potentiometric Multisensor for Simultaneous Analysis of Relevant Ions in Body Fluids

Area of Science:

• Analytical Chemistry
• Biomedical Engineering
• Sensor Technology

Background:

• Accurate monitoring of electrolytes (chloride, potassium, sodium, calcium) is crucial for human health.
• Existing methods for electrolyte analysis can be time-consuming and require complex sample preparation.

Purpose of the Study:

• To develop a novel potentiometric multisensor system for simultaneous determination of chloride, potassium, sodium, and calcium ions.
• To create a reliable and efficient platform for electrolyte monitoring in human body fluids.

Main Methods:

• Development of an integrated platform with four ion-selective paste electrodes featuring renewable sensing surfaces.
• Simultaneous conditioning, calibration, and analysis in mixed solutions containing all target ions.
• Application of the multisensor to diluted artificial saliva, sweat, and blood serum samples.

Main Results:

• The multisensor demonstrated near-Nernstian slopes, wide linear concentration ranges, high capacitance, and low potential drift.
• Successful application to biological samples with recovery values ranging from 97% to 108%.
• Significantly reduced analysis time due to simultaneous determination capabilities.

Conclusions:

• The developed potentiometric multisensor system is accurate and practical for simultaneous electrolyte monitoring.
• The system offers stable performance and repeated usability due to renewable sensing surfaces.
• This efficient platform provides a valuable tool for analyzing complex biological matrices.